Program

Sunday March 30: Arrival and registration at aquamare hotel.

 

Monday, March 31

BCL2 family and mitochondria

Chairs: Andreas Villunger & Thomas Kaufmann

9:00                      Welcome

9:05    Andreas Villunger: Introduction

9:15    Andreas Villunger: BH3-only proteins Bim and Bmf limit B cell survival in the absence of BAFF

9:30    Gabriel Ichim: Failure to execute apoptosis results in mitochondrial dependent DNA damage

9:45    Raquel Salvador Gallego: Microscopy approaches to investigate Bax dynamics and structure in living cells.

10:00  Luca L. Fava: Investigating the molecular mechanism of cell death upon mitotic arrest

10:15  Maja Sochalska: Investigating the role of Bcl2a1/A1/Bfl-1 in tumorigenesis

10:30                      Coffee break

11:00  Thomas Kaufmann: Investigating Molecular Functions of BOK and its Role in Cancer

11:15  Ameeta Kelekar: Noxa regulates glutamine metabolism through a mechanism independent of its BH3 domain

11:30  Dimitra Masouras: The role of IkB kinase (IKK) in the regulation of BH3-only proteins, downstream of cytokine signalling

11:45  Stephanie Bleicken: Structure of active Bax at the membrane

12:00  Matthias Kollek: Transient apoptosis inhibition in donor stem cells during hematopoietic stem cell transplantations

12:15  Nathiya Muthalagu: Bim is required and p19ARF is dispensable for Myc induced apoptosis in multiple solid tissues

13:00                      Lunch

Caspases, FLIP, the ripoptosome 

Chairs: Marion MacFarlane & Annika Meinander

15:05  Marion MacFarlane: Introduction

15:15 Michelle A. Hughes: The ‘FLIP’ side of the DISC – New Insights into c-FLIP Regulation of Caspase-8 Function

15:30 Jeanne A. Hardy: Allosteric Regulation of Apoptotic Caspases

15:45  Maximilian Wuerstle: Integrated data analysis demonstrates that Procaspase-9 is activated as a monomer on the apoptosome backbone

16:00  Sebastian Horn: The initiator caspase-10 protects from death receptor-induced cell death

16:15  Christian Widmann: Caspase-3 generates a NFkB repressor in response to stress

16:30                      Coffee break

17:00  Raffaella Iurlaro: Caspase-8 activation in response to glucose deprivation

17:15  Christian T. Hellwig: Employing a novel activation platform for the initiator caspase-8 to induce apoptosis in chemo-resistant cancer cells

17:30  Mason Sanders: Single cell analysis of inflammatory caspase activation

17:45  Dominique Kranz: Synthetic lethal RNAi screen identifies the atypical cadherin FAT1 as an antagonist of caspase-8

18:00  Annika Meinander: Negative regulation of DIAP2 activity and innate immunity by drICE

18:15  Gianmaria Liccardi: The ripoptosome: a double edged sword of the mitotic checkpoint

19:00                      Dinner

20:30  Poster session 1 – even-numbered posters

Tuesday, April 1

Autophagy and the lysosome       

Chairs: Monika Mortensen & Cristina Munoz-Pinedo

9:00    Monika Mortensen: short introduction

9:10    Tom Riffelmacher: Autophagy controls terminal differentiation of neutrophils

9:25    Anne Louise Hansen: Autophagy controls inflammation in the aging organism

9:40    Ghadir Almuhaini: HPV E6 Modulation of Autophagy

9:55    Sonja Aits: Galectins-1 as a novel marker for lysosomal membrane permeabilization

10:10  Søren Høgh: Regulation of lysosomal cell death by lysosomal ions and the TRPML1 ion channel

10:25                      Coffee break

Cell death in the immune system

Chairs: Gustavo P. Amarante-Mendes & Huseyin Mehmet

11:00  Julian Pardo : Fast and efficient in vivo elimination of chemoresistant leukemia cells overexpressing Bcl-XL by granzyme B of cytotoxic T cells

11:15  Maykel Arias: During a bacterial infection cytotoxic T cells employ the pro-apoptotic protease granzyme B to eradicate bacteria meanwhile inflammation induced by NK-derived granzyme A causes sepsis

11:30  Gustavo P. Amarante-Mendes: Novel role for galectin-1 in CTL killing

11:45  Anja Krippner-Heidenreich: Dendritic cell survival and maturation are differentially regulated by TNF receptors 1 and 2

12:00  Selma Tuzlak: Analysis of the role of anti-apoptotic A1/Bfl-1 in experimental autoimmune encephalomyelitis

13:00                      Lunch

Necroptosis and inflammation

Chairs: Seamus J. Martin & John Silke

15:00  Seamus J. Martin: Crosstalk between Cell Death and Inflammatory Signaling: Challenging Preconceptions

15:15 Scott McComb: Type-I Interferon Signalling is Necessary for Inflammatory Necroptosis of Macrophages

15:30  Monica Yabal: XIAP restricts TNF-dependent necroptosis and excessive inflammasome activation

15:45  Svetlana Saveljeva: Mechanism of ER Stress-Induced Necroptosis

16:00  Tania Løve Aaes: Necroptosis, a novel approach for cancer therapy?

16:15  Fumiyo Ikeda: Sharpin prevents TNFR1-induced keratinocyte apoptosis and skin inflammation by linear ubiquitination of FADD

16:30                      Coffee break

Inflammation and NF-kappaB

Chairs: Seamus J. Martin & John Silke

17:00  John Silke: At the crossroad of inflammation and cell death – is there a therapeutic angle?

17:15  Mar Orzaez: Identification of new inflammasome inhibitors targeting ASC-mediated caspase-1 activation

17:30  Karina Bortoluci: Role of lysosomal pathway induced by cytosolic flagellin in cell death and immunity

17:45  Dagmar Kulms: Identification of new IkBa complexes by an iterative experimental and mathematical modeling approach

18:00  Nima Etemadi: TRAF2 regulates canonical and non canonical NFkB signalling to inhibit cell death and inflammation in skin independently of Sphingosine Kinase 1

18:15 Tom Vanden Berghe: Simultaneous targeting of Interleukin-1 and -18 is required for protection against inflammatory and septic shock

19:00                      Dinner

20:30  Poster session 2 – odd-numbered posters

Wednesday, April 2

Death receptor signaling and IAPs

Chairs: Martin Leverkus & Giorgio Stassi

9:00    Mathieu JM Bertrand: An NF-kB-independent role of IKKs in regulating RIPK1 killing potential

9:15    Rebecca Feltham: MIB and SOB1 are novel RIPK1 interacting molecules that regulate TNF signaling by controlling the balance between survival and death

9:30    Thomas Grabinger: Mechanisms of TNF induced cell death in intestinal epithelial cells

9:45    Martin Leverkus: cFLIP regulates skin homeostasis and protects from  TNF-induced keratinocyte apoptosis

10:00  Joel S Riley: Identification of novel regulators of FLIP’s ubiquitination and degradation

10:15  Lynn Wong: IAPs and RIPKs modulate sensitivity to TNF induced apoptosis and cancer formation

10:30                      Coffee break

Ubiquitin and IAPs            

Chairs: Pascal Meier & Mads Gyrd-Hansen

11:00 Pascal Meier: Regulation of the ubiquitin E3 ligase cIAP1

11:15  Kate Lawlor: IAP proteins repress spontaneous inflammatory joint disease

11:30  Simone Wicki: Role of XIAP in murine neutrophils downstream of death receptors and in response to danger signals

11:45  Anna Aalto: Characterization of M1-linked linear ubiquitylation in NF-kappaB signaling in Drosophila

12:00: Solange Desagher: Reciprocal regulation of Trim17 and NFATc3: implication in neuronal apoptosis

12:15  Mads Gyrd-Hansen: The deubiquitinase OTULIN regulates LUBAC function and NF-kappaB activation through a direct interaction with HOIP

13:00                      Lunch

         social afternoon

Thursday, April 3

Cancer

Chairs: Vincenzo diLaurenzi & Jan-Paul Medema

9:00    Michael Hahne: The tubulin glycylase TTLL3 links primary cilia to colon cancer development

9:15    Paul A Townsend: Effect of histone deacetylase inhibitors on Notch signalling in the epidermis

9:30    Erik Slinger: CLL development is accelerated in mice deficient for pro-apoptotic regulator Noxa

9:45    Monika Mortensen: Targeting the autolysosomal compartment to improve acute leukemia treatment

10:00  Alessandro Annibaldi : The Role of the UBA domain of cIAP1 in Normal Cell Physiology and   Tumorigenesis

10:15  Najoua Lalaoui: New therapeutic strategy to sensitize primary cancer cells to SMAC mimetics: use of p38 inhibitors

10:30                      Coffee break

11:00  Mads Daugaard: Utilizing Plasmodium falciparum placental tropism to target a common oncofetal glycosaminoglycan signature on tumor cells

11:15  John Babcook: A Novel Antibody-Drug Conjugate Platform Demonstrating Potent Anti-Tumour Activity

11:30  Anette Brockmann: Thiazolides, GSTP1 and Colon Cancer Cell Apoptosis

11:45  Selcuk Colak: ER-stress induced UPR sensitizes chemotherapeutic resistant colon Cancer Stem Cells

12:00  Rosa Martín-Pérez: Cross-talk between Her2/ERBB2 signaling and the unfolded protein response in the regulation of apoptosis

13:00                      Lunch

and more Cancer

Chairs: Mads Daugaard & Huseyin Mehmet

15:00  Antonella De Cola: miRNA mediated down-regulation  of ErbB/HER receptors in Breast Cancer Stem cells results in targeted therapy resistance

15:15  Lisette Potze: New mechanistic insights in Betulinic acid-induced cell death

15:30  Cristina Muñoz-Pinedo: 2-deoxyglucose and glucose deprivation induce different forms of cell death

15:45 Gareth Miles: The Anti-Glycolytic Agent 2-deoxyglucose (2DG) Rapidly Activates the AMPK  Pathway and Enhances TRAIL and ABT-737 -Induced Tumour Cell Death in Leukaemic Cells

16:00  Vincenzo Graziano: A DAXX/PML pathway for regulation of Estrogen Receptor expression and cell fate in Breast Cancer Stem Cells

16:15                      Coffee break

 

Traditional EWCD football tournament

 

19:00 Dinner and party

Friday April 4

Breakfast and departure