Program

Sunday April 3rd

– Arrival

16:00-19:30 Registration

20:00 Dinner

 

Monday April 4th

8:30-9:00 Registration

9:15-9:30 Welcome address

9:30-10:45 -Session 1- CELL DEATH AND CANCER PROGRESSION

Chairs: Vincenzo De Laurenzi/ Michael Hahne

– Majorini Maria Teresa -Cellular inhibitor of apoptosis 1 (cIAP1)-mediated regulation of Snai2 in breast cancer metastatization.

– Fehrenbacher Nicole -Identification of GPR31 as a Novel Mediator of Kras Membrane-Association

– Kumar Gunjan– A urine chondroitin sulfate detection system informs on bladder cancer disease burden to predict efficacy of VAR2-based cytotoxic targeting strategies.

– Ausserlechner Michael– Nuclear, PKB-phosphorylated FOXO3 predicts adverse clinical outcome and promotes tumorangiogenesis of neuroblastoma tumors in vivo

– Rafn Bo -Oncogenic tyrosine kinase regulation of ROS in epithelial cells

10:45-11:15  Coffee Break

11:15-12:45 -Session 2- CELL DEATH AND CANCER PROGRESSION -2

Chairs: Jan Paul Medema / Gianluca Sala

– Daugaard Mads -Oncofetal glycosaminoglycans in cancer

– Schoeler Katia -Apoptosis via the miR-17~92-Bim axis in Development and Cancer

– Sorensen Poul -YB-1 regulates metabolic adaptation and cancer progression through selective mRNA translation

– Leeksma Alexander – SF3B1 mutations in cancer lead to an altered DNA damage response, and splice products that are substrates for nonsense-mediated decay

– Giammona Alessandro  Characterization of subcutaneous and visceral adipose-derived stem cells and their function in colon cancer.

– Aaboe Jensen Mads -RNA Therapeutics – developing a new class of drugs

13:00-15:00 Lunch

15:00-16:15 -Session 3- TNF family members and cancer

Chairs: Michael Hahne / Mads Daugaard

– Bertrand Mathieu JM -N-glycosylation of TRAIL-R restrains the sensitivity to TRAIL-induced apoptosis

– Peall Adam– Investigating the Mechanism of Protein Kinase C-mediated Inhibition of TRAIL-Induced Apoptosis

– Iurlaro Raffaella – Glucose deprivation induces FADD and caspase-8 dependent apoptosis through ATF4-mediated TRAIL-R2/DR5 up-regulation

– Manfroi Benoît – Tumor-derived CXCL-8 recruits APRIL-producing neutrophils in diffuse large B-cell lymphoma lesions

– van Attekum Martijn -Macrophages induce chronic lymphocytic leukemia cell survival via translational MCL-1 stabilization, independent of APRIL signaling

16:15-16:45 Coffee Break

16:45-18:30 -Session 4- Targeted cancer therapy

Chairs: Giorgio Stassi/Ulrich Maurer

– Pérez Silva Laura– Targeted melanoma therapeutics contribute to tumor relapse

– Del Mistro Greta Impact of sublethal drug doses on melanoma cell behavior and tumor relapse

– Roca Maria Serena Synergistic antitumor activity of histone deacetylase inhibitors and anti-ErbB3 antibody in NSCLC primary cultures via modulation of ErbB receptors expression.

– Sala Gianluca – HER-3: hub for escape mechanisms

– Babcook John -Translating Cancer Target Discovery Into Drugs

– Tabero Andrea – New combinational strategies to increase cell death in Photodynamic Therapy

– Martín-Antonio Beatriz Transfer of histone variant H2AZ from cord blood derived NK cells (CB-NK) to multiple myeloma cells (MM) is cytotoxic for MM cells. This cytotoxicity can be independent of CB-NK

19:30 Dinner

 

Tuesday April 5th

9:30-10:45 -Session 5- Cancer therapy

Chairs: Gerry Melino/Anastasis Stephanou

– Ellegaard Anne Marie-Repurposing cationic amphiphilic antihistamines for cancer treatment

– Jaime Paula -Immunogenicity of cytotoxic T cell-mediated cell death during cancer immunotherapy and its regulation by mutations associated with apoptosis resistance.

– Zimberlin Cheryl– Histone deacetylase (HDAC) inhibitors activate FOXOs in order to differentiate and sensitize colon cancer stem cells to chemotherapeutics

– Stephanou Anastasis-Tripterygium wilfordii, Amydalin and Graviola Induce cell death in Cancer Cells but not Normal Cells

Bornhauser Beat -Concurrent apoptosis and necroptosis by SMAC mimetics eradicates drug resistant leukemia

10:45- 11:15   Coffee Break

11:15-12:45 -Session 6- RIP AND CANCER

Chairs: Peter Vandenabeele / Paul Townsend

– Aguadé-Gorgorió Júlia -A novel role for TNF receptor II in RIP1-dependent SMAC mimetic-induced cell death in leukemia

– Silke John -The caspase-8 inhibitor emricasan combines with the Smac-mimetic birinapant to induce necroptosis and treat Acute Myeloid Leukemia

– Philipp Jost -Evasion of necroptosis and inflammasome activation promotes myeloid leukemogenesis

– Aaes, Tania Løve – RIPK3-dependent necroptosis induces efficient anti-tumor immunity

– Wong Lynn – RIPK3 promotes vascular permeability and angiogenesis independent of the kinase activity

– Eun-Woo Lee Crosstalk between necroptosis signalling and oncogenic signalling

13:15-15:00 Lunch

15:00-16:30 -Session 7- RIP AND INFLAMMATION

Chairs: Mads Gyrd-Hansen/Seamus Martin

– Feltham Rebecca -Mind bomb concomitantly regulates RIPK1 and its opposing deubiquitylase CYLD to prevent cell death during TNF signalling

– Liccardi Gianmaria – The Mitotic Ripoptosome: Guardian of genomic integrity and tissue homeostasis

– Schuler Fabian -Understanding the molecular basis of cell death triggered by inhibition of Check-point kinase 1

– Sladky Valentina -Dissecting the role of caspase-2 in “mitotic catastrophe”

– Annibaldi Alessandro -The E3 Ubiquitin ligases cIAP1 and cIAP2 differentially target RIPK1 to prevent cytokine-mediated apoptosis and necroptosis

– Bouchier-Hayes Lisa -DNA damage induces PIDD-dependent activation of caspase-2 in the nucleolus.

16:30-17:00 Coffee Break

17:00-19:00 POSTER VIEWING WITH APERITIF

19:00 dinner

 

Wednesday April 6th

9:15-10:45 -Session 8- CELL DEATH AND INFLAMMATION

Chairs: Julian Pardo/John Silke

– Martin Seamus – IL-1 family cytokines as the canonical DAMPs and their interplay with neutrophil-derived proteases

– Clancy Danielle -Neutrophil-derived proteases act as amplifiers of inflammation through processing and activation of multiple IL-1 family cytokines.

– Conos Stephanie -Cell death is not essential for caspase-1 mediated Interleukin-1b activation and secretion.

– Hrdinka Matous -RIPK2 active conformation but not its kinase activity is essential for pro-inflammatory signalling

– Lamkanfi Mo – ASC specks are cytosolic platforms for caspase-8 activation and apoptosis that is suppressed by cFLIPL upregulation through the TLR4/TRIF signaling axis

– Terrinoni Alessandro -Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis and inflammation in keratinocytes and in mouse psoriatic model

10:45-11:15    Coffee Break

11:15-13:00 -Session 9- ROLE OF UBIQUITIN IN CELL DEATH

Chairs: Pascal Maier/ Annika Meinander

– Gyrd-Hansen Mads -CYLD limits Lys63- and Met1-linked ubiquitin at receptor complexes to regulate innate immune signaling

– Damgaard Rune Busk -The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity

– Darding Maurice -Mechanistic insight into how LUBAC deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death

– Schlicher Lisa -SPATA2 a novel member of the TNFR complex I and interaction partner of CYLD

– Kumar Mohan Aravind -LUBE is a novel E3 ubiquitin ligase conjugating M1-linked chains in NF-kappaB signaling in Drosophila.

– Lionnard Loïc –Trim proteins regulate BFL-1 ubiquitination and degradation

– Zucca Mattia – Ubiquitin binding domains as a tool to investigate PRR signalling complexes

13:00-14:30 Lunch

Social afternoon- Visit to the old city of Anagni

19:00 dinner

 

Thursday April 7th

9:15-10:45 -Session 10- CELL DEATH IN NON MALIGNANT DISEASE 

Chairs: Katja Simon/ Marion McFarlane

– Desangher Solange -Characterization of a novel pathway regulating α-synuclein expression and neuronal death in Parkinson’s disease

– Granzotto Alberto -Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of alzheimer’s disease without reducing amyloid and tau pathology

– Delgado M.Eugenia -LRH-1-dependent regulation of TNF alpha-induced liver cell death

– Delvaeye Tinneke -Connexins as a new therapeutic target in the treatment of sepsis

– Townsend Paul Urocortin is chondroprotective through blockade of a non-selective cation channel: novel exploitable pathways for chondrocyte cytoprotection in osteoarthritis

– Xiao Mang MicroRNA (miR)-30 is responsible for radiation-induced apoptosis in mouse and human hematopoietic cells through targeting Mcl-1

10:45-11:15    Coffee Break

11:15-13:00 -Session 11- MOLECULAR MECHANISMS AND NEW METHODS

Chairs: Cristina Munoz Pinedo/Marja Jäättelä

– Melino Gerry-The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain

– Ruiz de Almodovar Carmen -Caspase-8 and FLIP as regulators of developmental angiogenesis

– Widmann Christian -Cellular homeostasis controlled by the caspase-3/RasGAP stress-sensing module

– Hughes Michelle The FLIP side of Death Receptor Signaling: New insights into c-FLIP regulation of Caspase-8

– Faletti Laura -Molecular mechanisms of TNFα sensitization to Fas/CD95-induced apoptosis

– McComb Scott -Multi-Colour LentiCRISPR Gene Disruption Demonstrates Caspase-3 and 7 Redundancy in Promoting Full Caspase-8 Activation and Apoptotic Cell Death

– Mørch Frøsig Merethe -Novel VitaBright™ probes can detect apoptosis based on thiol redox status

13:00-14:30 Lunch

14:30-16:15 -Session 12- ROLE OF MITOCHONDRIA AND AUTOPHAGY

Chairs: Chipuk, Jerry/Mehmet Hussein

– Chipuk Jerry Edward -BAX-dependent mitochondrial outer membrane permeabilization: exquisitely regulated to the point of death.

– Dewson Grant -VDAC2 is essential for Bax to efficiently mediate apoptosis

– Reljic Boris – A step closer to understanding Bax/Bak involvement in autophagy

– Riley Joel -An autophagy-independent pathway of mitochondrial clearance

Jäättelä Marja – Sphingomyelin regulates ATG9A trafficking and autophagosome closure

– Simon Katharina -Autophagy determines the fate of hematopoietic cells

– Gentle Ian -Autophagy

17:00-19:00 Traditional football tournament

20:00 Dinner and party

 

Friday April 8th

-Departure