Program

Sunday May 6, 2018              

Registration

20.00 Dinner

Monday May 7, 2018             

Breakfast

9:00 – 9:15 Introduction/welcome

09:15 Session 1 – Tumorigenesis
Chairs: Mads Daugaard; Peter Kreuzaler

Kai Cao, University of Glasgow
Apoptosis as an oncogenic driver – mechanism and impact on cancer

Thomas Kaufmann, University of Bern
Role of BOK in Cancer

Yuchen Guo, University of Montpellier
The role of cyclin A2 in colon homeostasis and colorectal cancer (CRC)

Michael Hahne, University of Montpellier
Primary cilia modulate susceptibility to colon carcinogenesis

Ulrike Hoeckendorf, Technical University of Münich
Evasion of LT–driven inflammatory cell death promotes myeloid leukemogenesis

10:30 Coffee break

11:00 Session 2 – Cancer invasion
Chairs: Mahvash Tavassoli; Brent Derry

Antonella De Cola, D’Annunzio University
MiR-205-5p promotes invasion and metastasis in breast cancer stem cells

Lazaros, Vasilikos, University of Zurich
Loss of cIAP1 in the tumor microenvironment disfavors cancer metastasis

Simone Di Franco, University of Palermo
Paracrine action of visceral adipose-derived mesenchymal stem cells promote the switch from epithelial (CMS2) to mesenchymal (CMS4) phenotype in colorectal cancer stem cells.

Peter Kreuzaler, Francis Crick Institute
Obligatory Tumour Heterogeneity driven by Myc Overexpression: Mechanistic Insights and Therapeutic Strategies

Seamus Martin, Trinity College
Stress-induced inflammatory functions  of ‘death receptors’

12:30 Lunch

15:00 Session 3 – Autophagy, ferroptosis
Chairs: Markus Conrad; Anne Hamacher-Brady

Ian Gentle, Universitätsklinikum Freiburg
Inhibitor of Apoptosis Proteins Regulate Autophagosome-Lysosome fusion

Kayleigh Frame, MRC Toxicology Unit
Dissecting the Link between Bioenergetic Status and Autophagy as a Mechanism of Tumour Cell Resistance to BH3 Mimetics

Samya Van Coillie, VIB Center for Inflammation Research
Novel third-generation ferrostatins protect against acute iron poisoning-induced organ injury

Lukas Peintner, University of Freiburg
The influence of apoptosis on the development of polycystic kidney disease (ADPKD)

Alessandro Terrinoni, University of Rome
The role of TGase3 in ultraviolet photodamage

16.30 Coffee break

17.00 Session 4 – Gamechanging Science I
Chairs: Uris Ros; Beat Bornhauser

Joyce Buikhuisen, Center for Experimental Molecular Medicine
CRISPR-based kinome knock-out screen identifies PAK2 as an essential kinase in poor prognosis mesenchymal colorectal cancer.

Janneke Linnekamp, Center for Experimental Molecular Medicine
Consensus Molecular Subtypes of colorectal cancer are recapitulated in in vitro and in vivo models.

Prashanthi Ramesh, LEXOR
A drug screen to identify optimal combination strategies to overcome BCL-xL specific stem cell resistance in colorectal cancer

Ulrich Maurer, University of Freiburg
CDK9-mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery

Laura Mainz, University of Würzburg
Arginine depletion induced senescence-like growth arrest facilitates senolytic therapy in pancreatic cancer cells

19.30 Dinner

21:00 Poster session 1 – No 1-49  

Tuesday May 8, 2018             

Breakfast

09:00 Session 5 – TNF signaling and inflammation
Chairs: Markus Rehm Morrison; Diana Panayotova-Dimitrova

Yves Dondelinger, VIB Center for Inflammation Research
Phosphorylation of RIPK1 Ser25 controls TNF-induced cell death and inflammation

Gianmaria Liccardi, Institute of Cancer Research
RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

Joanna Fox, MRC Toxicology Unit
Molecular Architecture and Mechanism of Death-Inducing Signalling Complex (DISC) Assembly

Rune Busk Damgaard, University of Cambridge
Interplay between TNF-secreting hyper-inflammatory cells and TNF-hypo-responsive cells prone to cell death in OTULIN-Related Autoinflammatory Syndrome (ORAS)

Carmen Palacios, Andalusian Center for Molecular Biology and Regenerative Medicine
Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis

10:15 Coffee break

10:45 Session 6 – Ubiquitin in cellular function
Chairs: Annika Meinander; Sheila Bohler

Anne Hamacher-Brady, Johns Hopkins University Bloomberg School of Public Health
Ubiquitin-Controlled Endolysosomal Interactions with Mitochondria Regulate Bax-Mediated Mitochondrial Permeabilization

Geert van Loo, VIB Center for Inflammation Research
The ubiquitin binding function of A20 critically controls its anti-inflammatory and protective activities

Anna Aalto, Åbo Akademi University
Lubel-mediated M1-linked ubiquitination as a regulator of hypoxia responses

Monica Yabal, Technical University of Munich
XIAP and inflammatory cell death in innate immunity.

Theresa Louise Boye, Danish Cancer Society Research Center
Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair

12:30 Lunch

15:00 Session 7 – Cell death proteins in hematopoietic function
Chairs: Andreas Villunger; Gianmaria Liccardi

Mattia Zucca, Ludwig Institute for Cancer Research
CYLD regulates the function of human macrophages

Lisanne Spilgies, University of Zurich
Inhibitors of Apoptosis Proteins (IAPs) regulate immune response to Influenza A infection

Ruoshi Peng, Ludwig Institute for Cancer Research
RIPK3-mediated inflammatory signalling in innate immune defence

Sheila Bohler, University of Freiburg
Deciphering the role of MCL-1 for maintenance of the human hematopoietic system

Christian Molnár, University of Freiburg
PUMA-mediated apoptosis of hematopoietic stem cells is a major driver of bone marrow failure in dyskeratosis congenita

16.30 Coffee break

17.00 Session 8 – Cell death and inflammation
Chairs: Marion MacFarlane; Rune Busk Damgaard

Diana Panayotova-Dimitrova, University Hospital RWTH Aachen
cFLIP isoforms regulate apoptosis/necroptosis decision in keratinocytes in vivo

Holly Anderton, Walter + Eliza Hall Institute of Medical Research
INHIBITOR OF APOPTOSIS PROTEINS (IAPS) LIMIT COMMENSAL DRIVEN INFLAMATION IN THE SKIN

Chris Wang, University of British Columbia
Oncofetal chondroitin sulfate modifications in NF-kB pathway activation

Wei-Lynn Wong, University of Zurich
XIAP inhibits excessive TNFR2-induced inflammation through RIPK1/TAK1

Yaron Fuchs, Technion Israel Institute of Technology
Caspase-3 Regulates YAP-dependent Cell Proliferation and Organ Size

19.30 Dinner

21:00 Poster session 2 – NR 50-98

Wednesday May 9, 2018      

Breakfast

09:00 Session 9 – Mitochondria – from powerhouse to slaughterhouse
Chairs: Cristina Muñoz-Pinedo; Rachel Uren

Ana J. Garcia-Saez, University of Tübingen
Mechanistic differences in Bax and Bak oligomerization at the single molecule level

Jerry Edward Chipuk, Icahn School of Medicine at Mount Sinai
MDM2 integrates cellular respiration and apoptotic signaling through NDUFS1 and the mitochondrial network.

Inge Verbrugge, Netherlands Cancer Institute
p32: From regulator of mitochondrial respiration to regulator of cell death?

Katiuscia Bianchi, Barts Cancer Institute
The innate immune kinase IKKε couples inflammation to aerobic glycolysis and serine metabolism.

Alba Roca Portoles, University of Glasgow
Mitochondrial stress signals inflammatory effects

Laura Hulea, McGill University
EIF4F Links Translation to Energy Stress Response in Cancer

10:30 Coffee break

11:00 Session 10 – Targeting bcl-2/mitochondria and cancer
Chairs: Stephen Tait; Ana Garcia-Sáez

Fabio Brocco, University of Amsterdam
BH3 mimetics as profiling tools: dissecting the role of individual Bcl-2 members in Venetoclax-resistant Chronic lymphocytic leukemia

Joan Montero, Institute for Bioengineering of Catalonia
Deciphering rational combination of targeted agents and BH3 mimetics using dynamic BH3 profiling

Marco Haselager, University of Amsterdam
Cross-talk between cytokine and NF-ĸB signaling in the CLL microenvironment can affect sensitivity for Venetoclax

Anna Guinot, University Children’s Hospital Zürich
Non-apoptotic cell death to eradicate resistant leukaemia

Karbon Gerlinde, Medical University of Innsbruck
Understanding the role of the BCL-2 protein family in the maintenance of genomic stability.

12:30 Lunch

14:00 off – social event

20.30 Dinner including round table discussions

Thursday May 10th 2018       

Breakfast

09:00 Session 11 – Necroptosis, death receptors and inflammation
Chairs: Mads Gyrd-Hansen; Anja Krippner-Heidenreich

Annette Jacobsen, Walter + Eliza Hall Institute of Medical Research
Compound X is a novel inhibitor of necroptosis in human cell lines.

Emma Petrie, Walter + Eliza Hall Institute of Medical Research
Formation of active human MLKL oligomers is tightly controlled by RIPK3.

Uris Ros, University of Tubingen
Structural insights into the auto-regulation of the necroptosis executor MLKL

Gabriela Brumatti, Walter + Eliza Hall Institute of Medical Research
RIPping leukaemias apart: Exploiting necroptosis to treat Acute Myeloid Leukaemia

Maximilien Bencze, UCL Great Ormond Street Institute of Child Health
Necroptosis participates in skeletal muscle degeneration in Duchenne Muscular Dystrophy

Graeme Sullivan, Trinity College
ER Stress-induced TRAIL receptor upregulation promotes inflammation

10:30 Coffee break

11:00 Session 12 – Gamechanging Science 2
Chairs: Gabriella Brumatti; Thomas Kaufmann

Mary Speir, Harvard Medical School
Negative regulation of apoptotic and necroptotic cell death by SHP1

Lisa Schlicher, Ludwig Institute for Cancer Research
Small-molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signalling

Ben Croker, Harvard Medical School
PAD4 negatively regulates neutrophil necroptosis

Paula Kroon, The Netherlands Cancer Institute
Hype, hope, or something in between? Achieving abscopal effects by radio-immunotherapy approaches

Nicole Rufo KU Leuven
Systems Biology of Immunogenic Cell Death (ICD) in Melanoma

Irmina Garcia-Carpio, Medical University of Innsbruck
Dissecting the molecular basis of sterile inflammation upon centrosome aberrations

12:30 Lunch

14:30  Session 13 – Gut
Chairs: Geert van Loo; Monica Yabal

Adam Wahida, Technical University of Munich
Molecular Characterization of the TNF-RIPK3-axis in Paneth cell Dysfunction and Dysbiosis as drivers of Inflammatory Bowel Disease in XIAP-Deficiency

Marc Healy, University Hospital Zurich
MCL-1 suppresses intestinal carcinogenesis by ensuring mucosal and stem cell homeostasis independent of microbiota-driven inflammation

Christa Kietz, Åbo Akademi University
drICE restrains DIAP2-mediated inflammatory signalling and intestinal inflammation

Eugenia Delgado, Ecole Polytechnique Federale de Lausanne
LRH-1-dependent regulation of intestinal epithelial cell death

Eric Chapman, University of Toronto
A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis in C. elegans

16:00 Football tournament

20.30 Gala Dinner

Friday May 11, 2018              

Breakfast

Wrap up and departure