Programme

Saturday February 23rd

15:00 – 19:00 Registration in Hotel Salobreña

19:00 Welcome reception in Salobreña town

21:00 Dinner in Hotel Salobreña

Sunday  February 24th

8:00 – 9:00 Breakfast

9:30 – 11:15   Expression and processing of TNF family members (Michel Hahne, Giorgio Stassi)

Kerstin Herzer: MECHANISM OF TGF-ß INDUCED APOPTOSIS IN HEPATOMA CELLS

Anne Grosse-Wilde: BIOCHEMICAL ANALYSIS OF MURINE TRAIL RECEPTORS

Raymond Daniels: TRAIL and TRAIL receptor expression in normal and malignant tissues.

Carmen Ruiz de Almodóvar: UP-REGULATION OF TRAIL RECEPTORS IN BREAST TUMOR CELLS UPON GENOTOXIC TREATMENT

Marta López Fraga: INTRACELLULAR PROCESSING OF APRIL, A TNF LIGAND FAMILY MEMBER

Marcello Pinti: GENETIC POLYMORPHISMS OF FAS (CD95) AND FASL  (CD178) IN HUMAN LONGEVITY: STUDIES ON CENTENARIANS

11:15 – 11:45 Coffee break

11:45 – 13:00 TNF like ligands: Biology and novel signalling (Giorgio Stassi, Michel Hahne)

Desiree Bonci: APRIL IS AN AUTOCRINE GROWTH FACTOR FOR MEGAKARYOCYTES

Alena Vaculová: Tumour necrosis factor-alpha-induced cell death in colon cancer cells

Wiebke Baum: IDENTIFICATION OF PROTEINS INTERACTING WITH THE INTRACELLULAR DOMAIN OF CD95LIGAND  

Christoph Wasem: REVERSE SIGNALLING VIA DEATH LIGANDS OF THE TUMOR NECROSIS FACTOR SUPERFAMILY

13:00 – 15:00 Lunch

15:00 – 16:45 Assembly and inhibition of signalling complexes (Henning Walczak, Ruggero De Maria)

Martin Sprick: Caspase-10 is recruited to and activated at death-inducing signalling complexes in a FADD-dependent manner

Tom Ganten: Enhanced Caspase-8 Recruitment to the DISC is Critical for Sensitisation of Human Hepatoma cells to TRAIL-induced Apoptosis BY CHeMOTHERAPEUTIC DRUGS 

Fabio Martinon: THE INFLAMMOSOME – A NOVEL SIGNALLING COMPLEX INVOLVED IN INFLAMMATORY CASPASE ACTIVATION

Adriana Eramo: CD95 SIGNALLING IS INITIATED IN LIPID RAFTS

Francesco Lozupone: CD95/EZRIN INTERACTION IN THE CD95 APOPTOTIC PATHWAY

Andreas Krueger: c-FLIP splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex (DISC)

16:45 – 17:15 Coffee break

17:15 – 18:30 Regulation of cell death 1: at receptor level (Ruggero De Maria, Henning Walczak)

Kristina Archer: MECHANISM OF DECOY RECEPTOR REGULATION OF TRAIL CYTOTOXICITY IN LYMPHOCYTES

Astrid Ruefli: Mechanisms of P-glycoprotein-mediated inhibition of Fas-induced cell death  

Cristina Muñoz-Pinedo: Inhibition of glucose metabolism sensitizes tumor cells to apoptosis induced by TRAIL, cd95 antibodies and tnf

Olivier Disson: REGULATION OF HEPATOCYTE APOPTOSIS IN A TRANSGENIC MODEL OF HCV INFECTION

20:00 Dinner

Monday February 25th

8:00 – 9:00 Breakfast

9:15 – 11:00 Regulation of cell death 2: by Bcl-2 family proteins (Jan Paul Medema, Marion MacFarlane)

Andreas Villunger: BMF: A PROAPOPTOTIC BH3-ONLY PROTEIN REGULATED BY INTERACTION WITH THE MYOSIN V ACTIN MOTOR COMPLEX, ACTIVATED BY ANOIKIS

Arlette Werner: DEFINING THE MECHANISM OF ACTION OF BFL-1,  A NOVEL INHIBITOR OF BID

Pilar Justo: MODULATION OF ACETAMINOPHEN INDUCED APOPTOSIS IN CULTURED MURINE TUBULAR EPITHELIAL CELLS BY BclxL AND INHIBITORS OF CASPASES

Paul Coffer: THE FORKHEAD TRANSCRIPTION FACTOR FKHR-L1 IS A CRITICAL EFFECTOR OF CELL DEATH INDUCED BY SURVIVAL FACTOR WITHDRAWAL

Barbara Marinari: Vav exchange factor blockS CD4-mediated signals, inducing Bax increase and mitochondrial damage

Penny  Lovat: GADD153 AND BAK:NOVEL MOLECULAR TARGETS OF FENRETINIDE-INDUCED APOPTOSIS

11:00 – 11:30 Coffee break

11:45 – 13:15 Regulation of cell death 3: at mitochondrial level and beyond (Marion MacFarlane, Jan Paul Medema)

Nigel Waterhouse: Single cell analysis of reactive oxygen species during mitochondrial outer membrane permeabiliSation

Geert Van Loo: Identification of tBid-induced release of mitochondrial proteins. Role of endonuclease G and Omi/HtrA2 in the apoptotic process

Marion MacFarlane: TRAIL-INDUCED APOPTOSIS RESULTS IN RAPID RELEASE OF SMAC AND ITS SUBSEQUENT DEGRADATION VIA THE UBIQUITIN-PROTEIN LIGASE ACTIVITY OF XIAP

John Silke: THE ROLE OF XIAP AND DIABLO/SMAC IN APOPTOSIS

Marie-Louise Brezniceanu:  IDENTIFICATION OF MAMMALIAN PROTEINS INHIBITING APOPTOSIS DOWNSTREAM OF CYTOCHROME C RELEASE

Klaus Schulze-Osthoff: Ionizing radiation but not cancer drugs causes G2/M cell cycle arrest and failure to activate the apoptotic pathway in breast carcinoma cells

13:15 – 15:00 Lunch

15:00 – 16:45 Regulation of cell death 4: Novel mechanisms (Eric Baehrecke, Nigel Waterhouse)

Gerolama Condorelli: MULTIPLE MEMBERS OF THE MITOGEN ACTIVATED PROTEIN KINASE FAMILY ARE NECESSARY FOR PED/PEA-15 ANTI-APOPTOTIC FUNCTION

Martin Leverkus: RESISTANCE TO TRAIL INDUCED APOPTOSIS IN PRIMARY KERATINOCYTES: A ROLE FOR EFFECTOR CASPASE INHIBITION

Grisha Pirianov: Rac is Involved in the Apoptotic Response of N1E-115 Neuroblastoma Cells to Staurosporine, but not to Ceramide

Eric Baehrecke: GENETIC REGULATION OF PROGRAMMED CELL DEATH DURING DROSOPHILA DEVELOPMENT

Arturo Sala: UNVEILING THE APOLIPOPROTEIN J SIGNALLING NETWORK: IMPLICATIONS FOR CELL SURVIVAL, PROLIFERATION AND ONCOGENESIS

Maria Fiammetta Romano: A.I.R. (APOPTOSIS-INDUCED AND REGULATOR), A NOVEL GENE THAT REGULATES APOPTOSIS

16.45 – 19.45 Poster Session with drinks and tapas sponsored by

20:00 Dinner

Tuesday February 26th

8:00 – 9:00 Breakfast

9:15 – 11:00 Regulation of cell death 5: extracellular factors (Vincenzo De Laurenzi, Cristina Muñoz-Pinedo)

Matilde Todaro: Th1and Th2 cytokines control cell survival in thyroid cancer by modulating apoptotic proteins

Concetta Conticello: INTERLEUKIN-4 PROTECTS TUMOR CELLS FROM CD178 AND CHEMOTHERAPIC AGENTS VIA UPREGULATION OF ANTIAPOPTOTIC PROTEINS

Igor Cima: IN SITU PRODUCTION OF GLUCOCORTICOIDS IN THE INTESTINE AS A REGULATOR OF LIFE AND DEATH IN INTESTINAL T-LYMPHOCYTES

Eric Eldering: MITOCHONDRIAL UNCOUPLING ACTIVATES CASPASE-9 AND MIMICS ANTIGEN RECEPTOR- INDUCED APOPTOSIS IN B-CELLS

Ann Zeuner: STEM CELL FACTOR UPREGULATES BCL-2 FAMILY MEMBERS AND PROTECTS ERYTHROID PRECURSOR CELLS FROM CHEMOTHERAPY-INDUCED APOPTOSIS

Anastasis Stephanou: RELATIVE CONTRIBUTION OF THE MITOCHONDRIA AND DEATH RECEPTOR SIGNALING PATHWAYS IN CARDIAC APOPTOSIS DURING ISCHAEMIA VERSUS REPERFUSION INJURY

11:00 – 11:30 Coffee break

11:30 – 12:45 DNA damage, p53 and p73 in cell death (Vincenzo De Laurenzi, Cristina Muñoz-Pinedo)

Christian Seemayer: FUNCTIONAL P53 RESPONSE IN RASF IN VITRO AND IN VIVO AND INVESTIGATION OF THE APOPTOSIS RESISTANCE AND PROLIFERATION OF RASF IN VITRO

Carine Maisse: Regulation of DeltaNp73: a dominant negative acting isoform.

Tobias Grob: dNp73 is induced by p53/TAp73 and exerts a dominant negative feedback loop

Eliana Munarriz: FLASH binds to p73 and regulates its function

12:45 – 14:30 Lunch

Free Afternoon

20:30 Dinner

Wednesday February 27th

8:00 – 9:00 Breakfast

9:30 – 11:15 Cell death in the nervous system (Huseyin Mehmet, Klaus Schulze-Osthoff)

Flavia Troglio: The neuronal specific adaptor protein Rai (ShcC) inhibits apoptosis triggered by limited neurotrophic support or environmental stress by activating PI3K/Akt

Adeline Lesay: BCL-2 PROTECTION FROM CYTOCHROME C-INDEPENDENT Apoptosis IN MAPLE SYRUP DISEASE

Jacqueline Beesley: MUTANT PROTEOLIPID PROTEIN TRIGGERS APOPTOSIS IN OLIGODENDROCYTES THROUGH AN ER STRESS PATHWAY INVOLVING CASAPSE-12 ACTIVATION

Huseyin Mehmet: Induction of Apoptosis or Necrosis in neuronal PC12 cells depending on the redox state of NITRIC OXIDE

Catherine Regnier: TRAF4 deficiency results in defective neurulation

Pier Giorgio Mastroberardino: TG2 ablation reduces neuronal death in a murine model of Huntington’s disease

11:15 – 11:45 Coffee break

11:45 – 13:00 Apoptotic signalling (Klaus Schulze-Osthoff, Huseyin Mehmet)

Jiang-yan Yang: The N-terminal caspase-generated RasGAP fragmant protects cells by activating the Ras-PI3K-Akt pathway

Daniela Barilá: REQUIREMENT OF ABL CASPASE CLEAVAGE IN APOPTOTIC SIGNALLING

Mohamed Lamkanfi: TRANSLATION INHIBITION IN APOPTOSIS: CASPASE-DEPENDENT PKR ACTIVATION AND eIF2-a PHOSPHORYLATION

Julieta del Prete: mRNA degradation: a general, early apoptotic event induced by a specific pathway distinct from that leading to DNA degradation

13:00 – 15:00 Lunch at conference site

15:00 – 17:00 Non-caspase proteases in cell death and survival (Katharina Simon, Marja Jäättelä)

Marja Jäättelä: HSP70 DEPLETION INDUCES CATHEPSIN-MEDIATED TUMOR CELL DEATH AND ERADICATES TUMOR XENOGRAFTS IN IMMUNODEFICIENT MICE

Maria Høyer-Hansen: INVOLVEMENT OF MITOCHONDRIA, ENDOPLASMATIC RETICULUM AND LYSOSOMES IN PROGRAMMED CELL DEATH OF MCF-7 BREAST CANCER CELLS

Nicole Fehrenbacher: TNF-INDUCED DEATH OF MURINE EMBRYONIC FIBROBLASTS BECOMES CATHEPSIN B-DEPENDENT UPON IMMORTALISATION

Michael Bots: THE SERINE PROTEASE INHIBITOR PI-9/SPI-6 BLOCKS THE PERFORIN/GRANZYME B PATHWAY, WHICH RESULTS IN ESCAPE FROM CTL-MEDIATED CYTOTOXICITY

Ingrid Kolfschoten: IDENTIFICATION AND EXPRESSION OF THE SERINE PROTEASE INHIBITOR SPICI

Lucy Peltenburg: c-Myc-mediated apoptosis in p53-negative human melanoma cells

Diane Bolton: DEATH OF CD4+ T CELL LINES CAUSED BY HUMAN IMMUNODEFICIENCY VIRUS-1 DOES NOT DEPEND ON CASPASES OR APOPTOSIS

17:00– 17:30 Coffee break                   

17:30 – 19:30 Tumor therapy and counterattack (Katharina Simon, Marja Jäättelä)

Mads Daugaard: Specific depletion of hsp70 mrna and protein by small interference rna

Jennifer Rohn: ACTIVATION AND TRAFFICKING OF THE TUMOR-SPECIFIC APOPTOSIS-INDUCING PROTEIN APOPTIN

Alexandra Pietersen: The tumor-specific apoptosis inducing protein Apoptin in a transgenic mouse model

Valentina Screpanti: mISSING- self Recognition bY Perforin-Deficient NK cells

Katharina Simon: Breaking tumour tolerance: Fas ligand induces an anti-tumour response to melanoma antigens

Frederik Igney: Tumor Counterattack: Level and Time-Point of CD95L Expression are not Critical Factors in Mice

Veronica Huber: SECRETION OF FASL-BEARING MICROVESICLES AS A NOVEL MECHANISM OF LYMPHOCYTE APOPTOSIS INDUCED BY TUMOR CELLS

20:00 Dinner and party

Thursday February 28th

7:30 – 9:00 Breakfast

Departure