Programme

Tuesday 11th May

Arrival and evening dinner 

Wednesday 12th May

7.30 – 9.00:  Breakfast 

9.00 – 11.00: Caspase-independent Death (Eric Baehrecke and Christophe Borner) 

Stephen Tait: Caspase-independent cleavage of Bid at aspartate is essential for DNA damage-induced apoptosis.

Lucy Peltenburg: A serine protease is involved in the initiation of DNA damage-induced apoptosis.

Lotti Egger: Caspase-independent, apoptosis-like cell death and phagocytosis mediated by serine proteases.

Colin Adrain: Proteomic identification of novel Granzyme B substrates .

Georg Duenstl: A serine protease-dependent mechanism of death receptor-induced apoptosis after caspase arrest.

Nicole Fehrenbacher: Tumorigenesis-associated sensitization to tumor necrosis factor-mediated cell death depends on cathepsin B .

Marie Stampe Andersen: A novel sigma2-receptor ligand as an inducer of caspase-independent death of cancer cells in vitro and in vivo.

11.00 – 11.30: Coffee break

11.30 – 13.15: Autophagy and others (Pascal Meier and Miguel Martins)

Eric Baehrecke: Autophagy genes function in an alternative cell death pathway.

Maria Høyer-Hansen: Bcl-2 inhibits autophagy via its localization to the ER.

Jacques Landry: Heat shock-induced non-apoptotic cell death mediated by protein aggregation.

Vanessa Zuzarte-Luis: BMP5- a new player in the control of interdigital cell death acting hrough Smad and MAPK signalling patwhays.

Alvin Joselin: Functional characterization of ASAP complexes in Apoptosis and RNA processing.

Michelangelo Campanella: The coxsackievirus 2B protein suppresses apoptotic host cell responses by manipulating intracellular Ca2+ homeostasis.

13.15 – 15.00: Lunch 

15.00 – 16.15: Neuronal Death / Ischaemia I (Ruggero De Maria and Klaus Schulz-Osthoff)

Katerina Sakoulas: Cytotoxicity of Cerebrospinal Fluid Samples from Human Infants with Cerebral Hypoxic-Ischaemic Injury Implicates CD95/Fas as a Major Component of the Inflammatory Response.

Kevin Lawrence: The cardioprotective effect of urocortin during ischaemia/reperfusion involves the prevention of apoptosis and mitochondrial damage.

Paul Townsend: BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome.

Huseyin Mehmet: Developmentally Regulated Changes in Apoptotic Stress-induced c-Jun N-Terminal Kinase Activation in the Oligodendrocyte Lineage

16.15 – 16.45: Coffee break

16.45 – 18.00: Neuronal Death / Ischaemia II (Huseyin Mehmet and Anastasis Stephanou)

Stefan Klussmann: Therapeutic Neutralization of CD95 Ligand Prevents Apoptosis and Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury .

Adriana Eramo: TRAIL resistance of glioblastoma cells by epigenetic silencing of caspase 8.

Susanne Kleber: New trials downstream of CD95 in the CNS.

Lucia Ricci-Vitiani: Double level of protection from death receptors and inflammatory cytokines in neural stem cells.

18.00-20.00: Posters 1 to 28

20.00: Dinner 

Thursday 13th May

7.30 – 9.00:  Breakfast 

9.00 – 11.00: Immunology and Inflammation (Jan Paul Medema and John Silke)

Douglas Green: A Physiological Function for TRAIL.

Katharina Simon: Fas Ligand (FasL): an adjuvant to generate monoclonal antibodies that reject tumour .

Lages Alves: Early induction of BH3-only protein Noxa in naïve CD8+ T cells after TCR triggering.

Michel Hahne: Distinct functions for APRIL in regulation of humoral responses.

Ajoy Samraj: The tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by regulating Bak expression.

Alberto Bosque: The mitochondrial apoptotic pathway in perforin/granzyme-induced apoptosis mediated by CTL effectors.

11.00 – 11.30: Coffee break

11.30 – 12.45: Mitochondrial Pathways (Marion MacFarlane and Giorgio Stassi)

Andreas Villunger: An essential role for the BH3-only protein Bim in the establishment of central tolerance.

Christoph Borner: Shuttling Bax from the cytosol to mitochondria: a complex business involving N- and C-termini.

Gavin McStay: Identification of a novel post-translational modification of Apaf-1 after apoptosome activation.

Cristina Muñoz-Pinedo: Mitochondrial intermembrane space proteins are released in a single step during apoptosis.

12.45 – 14.00: Lunch

14.00 – 19.00: Excursion to Istanbul

20.00: Dinner

Friday 14th May

7.30 – 9.00:  Breakfast

9.00 – 10.45: p53 and Family Members (Eric Eldering and Arturo Sala)

Jerry Chipuk: Direct Activation Of Bax By p53 Mediates Mitochondrial Membrane Permeabilization And Apoptosis.

W. Brent Derry: Assembling the p53 network in C. elegans by functional genomics.

Anastasis Stephanou: STAT1: a novel regulator of the apoptotic programme.

Miriam Erlacher: PUMA/bbc3, a key mediator of p53-induced apoptosis.

Hakan Akca: Cytokine-mediated induction of p53 and p21 is suppressed by EGF and insulin .

Vincenzo De Laurenzi: Identification of proteins regulating p73 function.

10.45 – 11.15: Coffee break 

11.15 – 13.15: Cancer I (Michel Hahne and Brent Derry)

Peter Daniel: Synergy between TRAIL and DNA damaging tumor therapies depends on Bax but not Bak.

Monica Zerilli: Th2 cytokines induce chemotherapy resistance in epithelial tumors via PI3K/AKT pathway.

Engin Ulukaya: Response of lung cancer patients to cisplatin-based anti-cancer treatments: Effects on the levels of cleaved cytokeratin 18 and sFas .

Kerstin Bellmann: The counteracting roles of the kinases Akt/PKB and p38 in c-Myc dependent apoptosis.

Emma Sanzari: PED controls B-chronic lymphocytic leukaemia cell apoptosis

Arturo Sala: B-MYB regulates the stress response though direct transactivation of key survival genes.

Satoshi Inoue: Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies.

13.15 – 15.00: Lunch 

15.00-16.30: Free Time

16.30-18.00: Cancer II (Peter Daniel and Engin Ulukaya)

Lourdes Planelles: Development of hyperplasia in aged APRIL transgenic mice.

Paul Chen: A Role for BAFF in Tumour Immunity.

Tobias Haas: Caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.

Eric Eldering: CD40 stimulation increases both the anti- and pro-apoptotic protein profile of B-CLL cells and renders them sensitive to autologous CTL-attack.

Till Wenger: Lentiviral expression of TRAIL in human tumor cells.

18.00-20.00: Posters 29-55

20.00: Dinner  

Saturday 15th May

7.30 – 9.00:  Breakfast

9.00 – 11.00: Caspases and their Substrates (Vincenzo De Laurenzi and Andreas Villunger)

 Seamus Martin: Understanding the demolition phase of apoptosis.

Antoine Tinel: Identification of a caspase-2 activating complex.

Thomas Hofmann: FLASH links CD95 (Fas/APO-1) signaling to a novel PML-nuclear body-associated apoptosis pathway.

Maya Saleh: Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.

Petra Ovaere: Caspase-14 expression, regulation and processing during epidermal differentiation.

Jiang-yan Yang: Partial cleavage of RasGAP by caspases is required for survival in mild stress conditions.

Xavier Saelens: Translational control in apoptosis versus necrosis.

11.00 – 11.30: Coffee break 

11.30 – 13.15: Inhibitor of Apoptosis Proteins (Seamus Martin and Cristina Munoz-Pinedo) 

Marion MacFarlane: Caspase activation impedes proteasome function during apoptosis: siRNA targeting of XIAP.

Pascal Meier: Ubiquitin-mediated regulation of cell death.

Tencho Tenev: Drosophila DIAP1 interacts with caspases through an evolutionarily conserved mechanism that is distinct from XIAP.

John Silke: Homeostatic regulation of IAP protein levels.

Luis Miguel Martins: Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.

José Rodriguez: A novel role for Survivin-DEx3: regulation of Aurora B sub-cellular distribution during interphase.

13.15 – 15.00: Lunch 
 
15.00 – 16.15: Death Receptors I (Katharina Simon and Henning Walczak) 

Martin Leverkus: cFLIPL inhibits TRAIL-mediated NF-kB activation and apoptosis induction in human keratinocytes.

Gustavo Ortiz-Ferron: Activation of the mitogen-activated protein kinase (MAPK) pathway attenuates TRAIL-induced apoptosis by preventing tBid-mediated release of cytochrome c from mitochondria in breast tumor cells.

Martin Sprick: Distinct but overlapping substrate specificities of caspase-10 and caspase-8.

Ann Zeuner: Ineffective death receptor signaling in polycythemia vera erythroid progenitor cells.

16.15 – 16.45: Coffee break 
 
16.45 – 18.00: Death Receptors II (Doug Green and Martin Leverkus)

 Annika Meinander:  Heat stress down-regulates c-FLIP and sensitises cells to Fas receptor-mediated apoptosis.

Inna Lavrik: CD95 signaling by the combination of bioinformatical and experimental approaches.

Ueli Nachbur: The role of lipid rafts in the regulation of Fas ligand activity.

Stefanie Fas: HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP).

19.00: Drinks Reception and Gala Dinner

Sunday 16th May

7.30 – 10.30: Breakfast

Departure