Sunday May 28th
15.00 – Registration
20.00 – Welcome Reception
Monday May 29th
9.00-11.15 Death in Cancer (Jan Paul Medema and Ricky Johnstone)
Ricky Johnstone: Defining the apoptotic pathways underlying histone deacytelase inhibitor-mediated tumor therapy.
Elza de Bruin: Role of intrinsic and radiotherapy-induced apoptosis in rectal cancer patients.
Dario Lombardi: Cytotoxic activity of normal and cancer neural stem cells through the production of death receptor ligands.
Arturo Sala: The double life of ApoJ/clusterin: an antiapoptotic protein inhibitor of neuroblastoma metastasis.
Mileidys Perez Alea: Cancer stem cells contribute to the aggressive behaviour of human epithelial colon cancer.
Maria Giovanna Francipane: Autocrine production of IL-4 confers resistance to chemotherapy and CD95-induced cell death in cancer cells.
Valeria Coppola: miR-15 and miR-16 induce apoptosis by targeting BCL2 in prostate cancer.
11.15-11.45 coffee break
11.45-13.15 Alternative Pathways (Eric Baehrecke and Marja Jäättelä)
Catherine Stenson: A more serine way to die? Investigating the role of serine proteases in leukaemic cell death.
Mads Gyrd-Hansen: Apoptosome-independent activation of lysosomal cell death pathway by caspase-9.
Mads Daugaard: Hsp70-2 controls the expression level of a potent cancer cell survival protein, Lens Epithelium Derived Growth Factor (LEDGF/p75).
Mélanie Denizot: Autophagy is involved in CD4+ T cell death triggered by HIV-1 envelope proteins.
Katja Simon: Autophagy and the immune system in vivo.
14.45-16.00 Alternative Pathways (discussion session)
Eric Baehrecke: Genetic regulation of autophagic programmed cell death.
Marja Jäättelä: Disruption of the lysosomal pH gradient combined with the inhibition of autophagosome formation, a new strategy for anti-cancer therapy?
Discussion on the role of alternative pathways in cell death
16.00-20.00 Poster Session + drinks
Posters (names A-L)
Tuesday May 30th
9.00-11.00 Caspase Regulation and Targets
Ina Lavrik: The role of two new c-FLIP proteins in life and death of cells.
Aura Kaunisto: Specific phosphorylation regulates the ubiquitylation and turnover of c-FLIP(S)
Christina Falschlehner: Caspase-3 and BID are differentially processed by Caspase-8 and Caspase-10.
Rüdiger Arnold: The caspase-3 target HPK1: A Molecular Switch between Life and Death in Hematopoietic Cells.
Magnus Olsson: A functional connection between p53 and Caspase-2 is essential for apoptosis induced by DNA damage.
Gavin McStay: In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.
Enrique Pérez-Payá: Small molecule inhibitors of apaf-1-related caspase-3/-9 activation that control mitochondrial-dependent apoptosis.
11.00-11.30 coffee break
11.30-13.15 Death Receptors
Thomas Kaufmann: Pro-Apoptotic BH3-only Bcl-2 Family Member Bid Is Required for FasL- but not for TNF-Mediated Fatal Hepatocyte Death and Dispensable for DNA Damage-Induced Apoptosis and Cell Cycle Arrest.
Brian Ferguson: Structural and biochemical analysis of the death domain complex formed at the Fas receptor.
Fiona Kimberley: Abnormal disulphide linked oligomers, global misfolding and intracellular retention of receptors underlies pathology in Tumour Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS).
Thomas Brunner: Loss of TRAIL protects from Fas (CD95)-induced hepatoxicity and lethality.
Anne Grosse-Wilde: The apoptosis-inducing TRAIL-receptor is a metastasis suppressor in a multi stage skin tumor mouse model.
Marion Macfarlane: Receptor-selective trail mutants reveal that primary lymphoid tumor cells signal to apoptosis via TRAIL-R1: implications for therapy.
14.30-21.30 Trip to castle + dinner
Wednesday May 31st
8.45-11.00 BH3 molecules (Andreas Villunger and Philippe Bouillet)
Philippe Bouillet: Mouse models to decipher the role of the BH3-only proteins in triggering apoptosis.
Verana Labi: The BH3-only protein Bmf has overlapping functions with Bim during cell death induction and B-cell development.
Paul Ekert: Cell death provoked by loss of Interleukin-3 signalling is independent of Bad, Bim, and PI3 Kinase/AKT, but depends in part on Puma.
Stephen Tait: Unconventional ubiquitination of Bid is required for its pro-apoptotic activity.
Miriam Erlacher: Combined loss of Bim and Puma mirrors the effects of Bcl-2 overexpression in some but not all forms of cell death.
Eric Eldering: Distinct expression levels of Noxa in peripheral versus lymph node chronic lymphocytic leukemia cells are linked with survival capacity.
Nuno Lages Alves: The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells.
Bernhard Gillisen: Nbk induces apoptosis via an ER pathway in a Bax-dependent manner.
11.00-11.30 coffee break
11.30-13.30 Mitochondrial Structure and Death
Lisa Bouchier-Hayes: Bax-mediated membrane permeabilization can occur in cells in the absence of mitochondrial membrane proteins.
Jerry Chipuk: Mitochondrial outer membrane permeabilization is directly regulated by the mitochondrial fission machinery.
Cristina Muñoz-Pinedo: Coordinate release of mitochondrial inter-membrane space proteins during apoptosis revealed by real time single cell analysis.
Patrice Petit: Cloning of the human cardiolipin synthase and effects of its knowkdown on cell death progression: a switch between apoptosis and necrosis.
Eric C.C. Cheung: Dissociating the dual roles of apoptosis inducing factor (AIF) in apoptosis and maintaining mitochondrial structure.
Franziska Mullauer: Betulinic acid induced cell death in cancer cells.
David Dickens: Identification of MAP4K3 as a putative tumor suppressor using an RNAi screen.
15.00-16.00 BH3-Mitochondria (discussion session)
16.00-20.00 Poster Session + drinks
Posters (names M-Z)
Thursday June 1st
9.00-10.45 Nuclear Aspects of “Death”
Vincenzo De Laurenzi: FLASH is an essential component of cajal bodies and is required for histone transciption and S-phase progression.
Brent Derry: Regulation of p53 by multiple SCF-based E3 ligases in C. elegans.
Catarina Grandela: Regulation of apoptosis of by p53 in human embryionic stem cells.
Paolo Salomoni: The role of Daxx in stress-induced cell death.
Paul Townsend: STAT-1: a modulator of apoptosis and cell cycle checkpoint responses.
Michael Ausserlechner: Regulation of Puma/bbc3 and Bcl-2 by p16INK4A sensitizes leukemia cells to Glucocorticoid- and Fas-induced apoptosis.
10.45-11.15 Lymphocyte-Associated Death (Nigel Watherhouse)
Ueli Nachbur: Post-transcriptional regulation of FasL killing activity by lipid rafts.
Ilia Voskoboinik: Unravelling the mechanism and function of perforin, a key effector molecule of the cytotoxic lymphocytes.
Nigel Waterhouse: Inhibition of caspases blocks granzyme B induced apoptosis in Bcl-2 over-expressing cells and promotes clonogenic survival
Michael Bots: The role of serine protease inhibitor SPI-6 in dendritic cells.
Carmen Ruiz-Ruiz: Regulation of primary T lymphocytes resistance to TRAIL-induced apoptosis
14.30-16.00 IAP family members
John Silke: Role of IAPs in TNF superfamily (TNFSF) signaling.
Martin Leverkus: Inhibition of IKK2 sensitizes human keratinocytes to (TNF)-induced apoptosis independent of cIAP2 upstream or at the level of caspase 8.
Markus Rehm: Effector caspase activation as an all-or-none response and its control by X-linked inhibitor of apoptosis protein (XIAP) – a quantitative systems biology analysis.
Paulo Ribiero: DIAP2, The drosophila orthologue of XIAP, controls the effector caspase DRICE through a novel mechanism.
Davina Twiddy: The ~700-kDa apoptosome complex directly processes caspase-7, which is then sequestered by XIAP into a stable ~200-kDa complex.
17.00-19.00 1st EWCD Football Cup (mixed)
20.00 BBQ and party
Friday June 2nd