Programme

Monday June 28th

9:00am – 10:45am Session I: IAPs in ubiquitin-mediated signaling (Mads Gyrd-Hansen)

John Silke The General Theory of TNF Signalling Relativity

Stefanie Cordier Identification of Sharpin as a novel functionally important component of the TNF-R1 and CD40 receptor signalling complexes

Martin Leverkus The role of cIAPs for cell death signalling by membrane-bound receptors

Maurice Darding Regulation of cIAP1’s E3-ligase activity.

Nele Vanlangenakker cIAP1, a modulator of TNF-induced necrosis

Nufail Khan cIAP antagonists and IFNγ activate caspase and RIPK1 dependant death pathways in transformed cells

10:45am – 11:15am Coffee Break

11:15am – 12:45pm Session II: Inflammatory signalling, cell death and cancer (Martin Leverkus)

Annika Meinander IAPs controls innate immunity by ubiquitin-dependent regulation of caspases

Rune Damgaard XIAP: from Inhibition of Apoptosis to Activation of Inflammatory Signalling in Cancer

Brian Ferguson Vaccinia virus inhibitors of apoptosis and innate immunity.

Michael Hahne Anti-inflammatory IL-10 producing B cells are modulated by the TNF-ligand APRIL.

L. Fernández-Zabalegui The TNF-ligand APRIL promotes colon carcinoma formation, but has a rather protective role in colitis

12:45pm 2:30pm Lunch

2:30pm – 4:00pm Session III: Cancer cell survival (Paul G Ekert)

Ulrich Maurer Phosphorylation of Tip60 by GSK-3 determines the decision for apoptosis induction by p53

Mads Daugaard Cancer cell survival factor LEDGF/p75 promotes high fidelity DNA repair after genotoxic stress

W. Brent Derry Synthetic lethal interactions in the p53 network

Susanne Svensson Chk1 inhibitors lead to premature cdc2-cyclin B1 activation and mitotic catastrophe in lung cancer stem cells

Felipe De Sousa E Melo Wnt signalling is related to cancer stem cell maintenance and therapy Resistance

4:00pm – 4:30pm Coffee Break

4:30pm – 6:00pm Session IV: Bcl2-family and apoptosis (Pascal Meier)

Douglas R. Green A Unified Model of BCL-2 Family Function

Nohemy Echeverry Analysing the Function of the Bcl-2 Family Member Bok

Jerry E. Chipuk The BH3-only protein Puma Induces BCL-XL domain-swapped dimerization that mediates apoptotic signaling

Mark Cragg Maximal killing by DNA damaging chemotherapy requires Bim in addition to Puma and Noxa

Poster Session I 6:00pm 8:00pm

Gabriela Brumatti Regulation of Bcl-2 family members by HoxA9: From cell death to differentiation

8pm – 10pm Dinner

BAR…..

Tuesday June 29th

9:00am – 10:30am Session V: Bcl2-family in development (Katja Simon)

Eric Eldering Darwinistic selection following T cell activation: the Noxa/Mcl-1 axis constitues a survival threshold set by TCR affinity and IL-2 signaling

Felix M. Wensveen BH3-only protein Noxa mediates selection of high-affinity clones during antigen-driven interclonal B cell competition

Daniela Bertele The role of pro-apoptotic BH3-only proteins during engraftment and reconstitution of human haematopoietic stem cells

Claudia Woess Investigating the role of BH3-only proteins in B cell development

Paul G Ekert The Regulation Of Puma In Life And Death

10:30am – 11:00am Coffee Break

11:00am – 12:15pm Session VI: Bcl2-family in cancer (Ricky W Johnstone)

Florian Baumgartner Investigating the Role of the BH3-only Proteins Bim and Bmf in Mammary Gland Development, Cancer and Metastasis

Michaela Waibel Targeting pro-survival Bcl-2 proteins in haematological malignancies driven by activated mutant JAK2.

Seamus J Martin Bcl-2 family proteins as modulators of oncogenic Ras-induced cell death

Cassandra Vandenberg Apoptosis-promoted tumorigenesis: Puma-driven leukocyte death allows thymic lymphomagenesis

Lunch 12:15pm 1:45pm

Social Afternoon: Trip to Copenhagen The bus leaves at 1:45pm and we return at ca. 11:30pm

Wednesday June 30th

9:00am – 10:30am Session VII: Apoptosis and ubiquitin (Henning Walczak)

Pascal Meier Regulation of apoptosis by ubiquitin and ubiquitin-like proteins

Mike Hupe cIAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitmen

Inge Verbrugge MARCH ubiquitin ligases dictate TRAIL-Receptor 1 membrane expression and TRAIL sensitivity in human tumor cells

Christophe Le Clorennec The Role of the new c-FLIP binding protein Ku70 in Death Receptor mediated apoptosis: The DUB Ku70: Novel regulator of c-FLIP function.

Philipp Jost Apoptotic Regulation by IAPs in the Liver

10:30am – 11:00am Coffee Break

11:00am – 12:30pm Session VIII: Caspases and Apoptosis I (John Silke)

Cristina Muñoz-Pinedo DeathBase: a database on structure, evolution and function of proteins involved in apoptosis and other forms of cell death.

Thomas Kaufmann Analysing the Crosstalk from the Death Receptor to the Mitochondrial Apoptotic Pathway

Maike A Laussmann Proteasome inhibition induces FADD-dependent caspase-8 activation

Lisa Bouchier-Hayes Characterization of Cytoplasmic Caspase-2 Activation by Induced Proximity

Andreas Villunger Investigating the enigma of caspase-2

Lunch 12:30pm 2:30pm

2:30pm – 4:00pm Session IX: Caspases and Apoptosis II (Seamus Martin)

Rosario Yerbes Cellular FLIPL plays a survival role and regulates morphogenesis in breast epithelial cells.

Ueli Nachbur Kupffer cells, canaries in the coal mine of liver damage or ticking time bombs?

Zofia Kirejczyk Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells

Julian Pardo Pleiotropism of granzyme B-induced cell death; A means of the host to counter pathogen (tumor) evasion strategies of Tc cell-mediated recovery

Sean Cullen Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

4:00pm – 4:30pm Coffee Break

4:30pm – 6:00pm Session X: Autophagy and alternative cell death (Jan Paul Medema)

Stephen Tait Resistance to caspase-independent cell death requires persistence of intact mitochondria

Thomas Kirkegaard Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated pathology

Amanda Stranks Characterisation of autophagy deficient Atg 7-/- Macrophages

Anne Keldsbo Autophagy induced by DNA damaging agents.

Monika Mortensen Spontaneous development of leukaemia in the absence of autophagy (Atg7) in vivo

Poster Session II 6:00pm 8:00pm

8pm – 10pm Dinner

BAR…..

Thursday July 1st

9:00am – 10:45am Session XI: Anti-cancer treatments (Mahvash Tavassoli)

Marion MacFarlane A TRAIL-R1-specific Ligand in combination with Doxorubicin selectively targets Primary Breast Tumour Explants for Apoptosis

Ricky W Johnstone Molecular characterisation of HDAC inhibitor-induced death in a mouse model of acute myeloid leukaemia

Catarina Grandela Strategies to target and eradicate Colon Cancer Stem Cells

Helen M. Beere Inhibition of Hsp90 via 17-DMAG Induces Apoptosis in a p53-Dependent Manner to Prevent Medulloblastoma.

Oliver Hill Treatment of Glioblastoma Multiforme with the CD95-Ligand antagonist APG101

Kerstin Papenfuss ATM-independent TRAIL sensitisation by the ATM-inhibitor KU-55933 reveals a novel mitochondria-independent treatment option for cancer

10:45am – 11:15am Coffee Break

11:15am – 12:45pm Session XII: Metabolism, Apoptosis and Cancer (Huseyin Mehmet)

Ceyda Acilan The role of reactive oxygen species on smooth muscle cell apoptosis in thoracic aortic aneurysms

Alfredo Caro-Maldonado Molecular mechanisms of cell death induced by inhibition of the glycolitic metabolism

A. Pradelli Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMPLudivine Kinase activation leading to Mcl-1 block in translation

Poul H.B. Sorensen Dominantly-transforming oncoproteins modulate responses to nutrient deprivation by deregulating eEF2 kinase and translation elongation.

Gemma Robinson Switching from aerobic glycolysis to oxidative phosphorylation modulates tumor cell sensitivity to TRAIL

Lunch 12:45pm 2:30pm

EWCD football Cup 3:00pm – 5:30pm

Dinner and Party 7:00pm – END

Friday July 2nd

DEPARTURE