Sunday, June 26 2022
20:00 Arrival and Dinner
Monday, June 27 2022
09:00 Welcome
The powerhouse: mitochondria
Chairs: Lisa Bouchier-Hayes and Marc Healy
| 09:15 | 26 | Mitochondrial Contributions To Cancer: Causes, Consequences, & Coincidence | Jerry Edward Chipuk |
| 09:30 | 133 | Disruption of a novel TAp73/OPA1 axis drives mitochondrial dysfunction and sensitivity to apoptosis | Niall Buckley |
| 09:45 | 144 | Sublethal Cytochrome-c release generates drug-tolerant persisters | Halime Kalkavan |
| 10:00 | 61 | tBID can directly elicit MOMP acting as a BAX-like effector of apoptosis | Hector Flores-Romero |
| 10:15 | 109 | Mitochondrial ubiquitylation initiates inflammation during cell death | Esmee Vringer |
10:30 coffee break
Did you flip your mito?
Chair: Uris Lianne Ros Quincoces and Cathrin Hagenlocher
| 11:00 | 28 | Mechanistic insights into the relationship of TNFR2, interferon regulated genes and inflammasome | Stefanie Rufli |
| 11:15 | 49 | Recombinant lactaptin analogon RL2 inhibits TRAIL-induced cell death in breast cancer cell lines by mitophagy | Fabian Wohlfromm |
| 11:30 | 32 | Role of cFLIP in TNF-induced cell death, inflammation viral response and tissue homeostasis | Kristel Martinez Lagunas |
| 11:45 | 41 | Combined treatment with small molecules targeting c-FLIP and Mcl-1 promotes apoptosis and necroptosis in pancreatic cancer cells | Corinna König |
| 12:00 | 92 | UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL K63/K48 branched polyubiquitination leading to Ku70 and c-FLIPL proteasomal degradation and enhanced neuroblastoma HDACi-mediated caspase 8 dependent apoptosis. | Christophe Le Clorennec |
12:30 Lunch
Immune response
Chair: Motti Gerlic and Lynn Wong
| 14:00 | 71 | Role of Leukocyte-derived extracellular vesicles in Multiple Sclerosis : a proteomics study | Damiana Pieragostino |
| 14:15 | 83 | Inhibition of Syk kinase pathway limits pro-inflammatory cell death and immune response of HoxB8 macrophages in the periodontitis in vitro model | Alicja Płonczyńska |
| 14:30 | 121 | Neutrophils: the inflammatory conductors of Kawasaki Disease and MIS-C? | Ben Croker |
| 14:45 | 127 | Activation of NLRP3 inflammasome by two novel T6SS effectors | Hadar Cohen |
| 15:00 | 150 | ZBP1 induces inflammatory signaling via RIPK3 and promotes SARS-CoV-2-induced cytokine expression | Mads Gyrd-Hansen |
| 15:15 | 54 | Met1-linked ubiquitination facilitates NF-κB activation and survival during sterile inflammation | Anna Aalto |
16:00 Coffee break
Modifications R us
Chair: Ana Garcia and Chris Kedong Wang
| 16:30 | 95 | On the trail of how the unfolded protein response and the cancer cell glycocalyx are linked | Maj Sofie Ørum-Madsen |
| 16:45 | 112 | Impaired N-glycosylation due to glucose deprivation promotes LIF-dependent angiogenesis | Cristina Muñoz Pinedo |
| 17:00 | 128 | Conformationally altered hyaluronan blocks the progression of cancer and neurodegeneration via in part altering gut microbiota | Nan-Shan Chang |
| 17:15 | 159 | M1-ubiquitination is required for caspase-mediated induction of the Drosophila IKK complex | Annika Meinander |
19:30 Dinner
21:00 poster session I (P1 – P23)
Tuesday June 28 2022
Ferroptosis
Chair: Kathrin Weber and George Skalka
| 09:00 | 48 | A shark fin loop-like structure of GPX4 is essential for its anti-ferroptotic function | Adam Wahida |
| 09:15 | 79 | Molecular underpinnings of ferroptosis in neurodegeneration | Svenja Lorenz |
| 09:30 | 85 | Localized and scalable hydrogen peroxide challenges are potential triggers of ferroptotic cell death | Jiashuo Zheng |
| 09:45 | 101 | Inhibiting anti-apoptotic Bcl-2 family members modulates GPX4 inhibitor-induced ferroptosis | Yun Qiu |
| 10:00 | 157 | Ewing sarcoma cells utilize multiple mechanisms to block ferroptosis by maintaining cellular cysteine and glutathione pools | Poul Sourenson |
10:15 Coffee break
Cancer Transformation
Charir: Ivano Amelia and Eugenia Delgado
| 10:45 | 33 | Altered spindle assembly checkpoint function impairs B cell survival but facilitates their MYC-driven transformation | Johannes Weiss |
| 11:00 | 47 | PLK4-driven PIDDosome activation limits DNA damage-driven lymphomagenesis | Vincent Braun |
| 11:15 | 68 | Recapitulating thyroid cancer histotypes through engineering human embryonic stem cells | Francesco Verona |
| 11:30 | 53 | TCOF1 as a nucleolar caspase-2 substrate to mediate the nucleolar DNA damage response | Alexandra Brown-Suedel |
| 11:45 | 62 | SETD8-mediated p53 inactivation as an early prerequisite of inflammation-induced colorectal cancer | Veronica Veschi |
12:30 Lunch
Targeting blood cancers
Chair: Michael Hahne and Veronica Veshi
| 15:00 | 97 | The role of nucleophosmin 1 mediated caspase-2 regulation in AML cell death and cell survival | Dharaniya Sakthivel |
| 15:15 | 99 | Ibrutinib treatment interrupts TLR9-induced CD40 upregulation in the lymph node thereby sensitizing CLL cells to venetoclax | Karoline Kielbassa |
| 15:30 | 110 | No role of death receptors in regulating cell death upon endoplasmic reticulum stress in B cell malignancies | Demi Both |
| 15:45 | 134 | Modulating necroptosis to overcome apoptosis resistance in leukemia | Anna Saorin |
| 16:00 | 141 | Gasdermin E-dependent pyroptosis determines drug sensitivity in leukemia | Mahya Eslami |
16:15 Coffee Break
Tumor microenviroment: who said what?
Chair: Maja Sochalska and Simone di Franco
| 16:45 | 45 | Mechanisms of Immunogenic Cell Death in Human Tumour Cells infected with Oncolytic Viruses | April D’Arcy |
| 17:00 | 57 | Ptk7 regulates the crosstalk between colonic epithelial cells and fibroblasts and thus colon homeostasis and pathology | Monica Gabola |
| 17:15 | 59 | Tumour cell death induced by cytotoxic T cells is immunogenic and primes caspase-3 dependent spread immunity against endogenous tumour antigens. | Iratxe Uranga-Murillo |
| 17:30 | 104 | TRAIL receptors participate in pro-tumorigenic IL-8 secretion in non-small cell lung carcinoma | Francesca Favaro |
| 17:45 | 118 | An in Vitro Model for Evaluation of DAMPs Impact on Cancer Cell Viability Mimmicing Processes Occuring in Tumour Microenvironment During/After Application of Irreversible Electroporation (IRE) | Jakštys Baltramiejus |
| 18:00 | 77 | Cancer cell killing by bispecific antibodies or CAR T cells is partly by necroptosis, with release of immunomudulators | Eric F Eldering |
19:30 Dinner
21:00 poster session II (P24 – P45)
Wednesday June 29 2022
Targeting cancers II
Chair: Esmee Vringer and Nader al Nakouzi
| 09:00 | 69 | Netrin-1 blockade triggers tumor cell death through UNC5B dependent Mcl-1 degradation | Ambroise Manceau |
| 09:15 | 73 | Targeting BAK-dependent cell death by modulating the interaction with regulatory tyrosine kinase BMX for the treatment of cancer | Joanna Fox |
| 09:30 | 81 | TARGETING M1-UBIQUITINATION IN INFLAMMATION-INDUCED CANCER | Gabriela Martínez-Chacón |
| 09:45 | 132 | MBoINs: first-in-class drugs interfering MCL1-BOK interaction | Diego Leiva |
| 10:00 | 145 | Regulation and targeting of chondroitin sulfate glycosaminoglycans in prostate cancer | Nader Al Nakouzi |
| 10:15 | 89 | LGALS3BP as a novel target for non-internalizing antibody drug-conjugates therapy | Emily Capone |
10:30 coffee break
Metastasis
Chair: Mads Daugaard and Gabriela Martínez-Chacón
| 11:00 | 74 | Unveiling TC metastatic origin and evolution via a barcode-mediated phylogenetic analysis | Vincenzo Davide Pantina |
| 11:15 | 137 | Anti-metastatic potential of usnic acid derivative against pancreatic cancer cells | Mariola Gimła |
| 11:30 | 153 | Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma | Dagmar Kulms |
12:30 Lunch
14:00 Free time – Wine tasting, spa activities
19.30 Dinner including round table discussions
Thursday, June 30 2022
Game changing science
Chair: Eric Eldering and Nastaran Khazamipour
| 09:00 | 90 | Reciprocal compensation of p53 and caspase-2 in the DNA damage response. | Karla E. Lopez |
| 09:15 | 88 | Blockade of BAG3 protein impairs adverse remodeling and preserves cardiac function in a murine model of myocardial injury | Anna Lisa Cammarota |
| 09:30 | 94 | Caspase-2 activation during the cell cycle is independent of PIDD and RAIDD | Ashley Boice |
| 09:45 | 96 | Repression of BIM by miR-17-92 is vital for normal lung development | Katharina Hoppe |
| 10:00 | 151 | p53 prevents genomic instability preserving epigenetic integrity | Ivano Amelio |
10:15 Coffee Break
Metabolism
Chair: Katia Cosentia and Markus Morrison
| 10:45 | 42 | Elongation control of mRNA translation drives Group 3 medulloblastoma adaptation to nutrient deprivation | Alberto Delaidelli |
| 11:00 | 55 | Lipid metabolism defines sensitivity towards BH3-mimetics in colorectal cancer | JP Medema |
| 11:15 | 64 | BAG3 in glucose homeostasis: physio-pathological characterization of BAG3 knockout in pancreatic β-cells | Verena Damiani |
| 11:30 | 111 | The role of p53 in B cell malignancies: cell death versus metabolic consequences | Chiara Montironi |
| 11:45 | 113 | A plasma metabolomic signature of head and neck paraganglioma | Simone De Fabritiis |
12:30 Lunch
Die, die and die… in any way
Chair: Cristina Muñoz Pinedo
| 14:30 | 44 | Identifying and characterising novel cell death regulators of TRAIL-dependent cholangitis-like liver injury | Anna Gabrielyan |
| 14:45 | 75 | BAX and BAK: distinct interplayers in the growth dynamic of the apoptotic pore | Katia Cosentino |
| 15:00 | 138 | Calcium signaling in cell death and survival | Uris Ros |
| 15:15 | 143 | TLR3 employs the necroptotic effector protein MLKL to trigger lysosomal cell death in caspase-8 deficient cancer cells | Kathrin Weber |
16:00 Football tournament
20.30 Gala Dinner
Friday, July 1 2022
Wrap up and departure