7:30-8:15 Breakfast
8:30-10:00 Session V: TRAIL Signaling (H. Walczak/J. Borst)
Henning Walczak: TRAIL-induced apoptosis is not inhibited by overexpression of Bcl-2 or Bcl-XL.
Juthathip Mongkolsapaya: Structure of the apoptosis inducing TRAIL-DR5 complex.
Martin Sprick: Caspase-8 and FADD/Mort1 are necessary components of the TRAIL-R2 death-inducing signalling complex (DISC).
Marion MacFarlane: Active effector caspases and cleaved cytokeratins are sequestered into cytoplasmic inclusions following TRAIL-induced apoptosis.
10:00-10:30 Coffee break
10:30-11:25 Session VI: TRAIL Biology (H. Walczak/M. Hahne)
Markus Weigand: Differential regulation of the CD95- and TRAIL-system on human peripheral T-lymphocytes.
Katharina Simon: Involvement of TRAIL receptor 2 in thymic negative selection.
Martin Leverkus: Regulation of TRAIL sensitivity in primary and transformed human keratinocytes.
11.25-13.00 Session VII: Clinical aspects of apoptosis (G. Condorelli/G. Stassi)
Giorgio Stassi: FLIP (FLAME-1/I-FLICE) and Bcl-XL protect thyrocytes from Fas-mediated destruction in Graves’ disease.
Gianluigi Condorelli: Apoptotic pathways in cardiomyocytes.
Thomas Brunner: Cyclosporin A-insensitive CD95 (Fas) ligand expression in the pathogenesis of acute intestinal Graft-versus-Host Disease.
Corina Lorz:Â Proapoptotic FasL is present in normal kidney tubules and inflammed glomeruli.
Marcello Pinti: Quantitative analysis of CD95 and CD95L mRNA expression in HIV infection.
13:00-14:30 Lunch at conference site
20:00 Dinner at the conference site