9:00am – 10:45am Session I: IAPs in ubiquitin-mediated signaling (Mads Gyrd-Hansen)

John Silke The General Theory of TNF Signalling Relativity

Stefanie Cordier Identification of Sharpin as a novel functionally important component of the TNF-R1 and CD40 receptor signalling complexes

Martin Leverkus The role of cIAPs for cell death signalling by membrane-bound receptors

Maurice Darding Regulation of cIAP1’s E3-ligase activity.

Nele Vanlangenakker cIAP1, a modulator of TNF-induced necrosis

Nufail Khan cIAP antagonists and IFNγ activate caspase and RIPK1 dependant death pathways in transformed cells

 

10:45am – 11:15am Coffee Break

11:15am – 12:45pm Session II: Inflammatory signalling, cell death and cancer (Martin Leverkus)

Annika Meinander IAPs controls innate immunity by ubiquitin-dependent regulation of caspases

Rune Damgaard XIAP: from Inhibition of Apoptosis to Activation of Inflammatory Signalling in Cancer

Brian Ferguson Vaccinia virus inhibitors of apoptosis and innate immunity.

Michael Hahne Anti-inflammatory IL-10 producing B cells are modulated by the TNF-ligand APRIL.

L. Fernández-Zabalegui The TNF-ligand APRIL promotes colon carcinoma formation, but has a rather protective role in colitis

 

12:45pm 2:30pm Lunch

2:30pm – 4:00pm Session III: Cancer cell survival (Paul G Ekert)

Ulrich Maurer Phosphorylation of Tip60 by GSK-3 determines the decision for apoptosis induction by p53

Mads Daugaard Cancer cell survival factor LEDGF/p75 promotes high fidelity DNA repair after genotoxic stress

W. Brent Derry Synthetic lethal interactions in the p53 network

Susanne Svensson Chk1 inhibitors lead to premature cdc2-cyclin B1 activation and mitotic catastrophe in lung cancer stem cells

Felipe De Sousa E Melo Wnt signalling is related to cancer stem cell maintenance and therapy Resistance

 

4:00pm – 4:30pm Coffee Break

4:30pm – 6:00pm Session IV: Bcl2-family and apoptosis (Pascal Meier)

Douglas R. Green A Unified Model of BCL-2 Family Function

Nohemy Echeverry Analysing the Function of the Bcl-2 Family Member Bok

Jerry E. Chipuk The BH3-only protein Puma Induces BCL-XL domain-swapped dimerization that mediates apoptotic signaling

Mark Cragg Maximal killing by DNA damaging chemotherapy requires Bim in addition to Puma and Noxa

Poster Session I 6:00pm 8:00pm

Gabriela Brumatti Regulation of Bcl-2 family members by HoxA9: From cell death to differentiation

 

8pm – 10pm Dinner

BAR…..