7:00 – 9:00 Breakfast
9:00 – 10:15 Role of IAPs in physiology and disease (Pascal Meier / Martin Leverkus)
Ueli Nachbur: A physiological role for IAPs?
Meike Broemer: Ubiquitin-mediated regulation of caspases by DIAP1
Mads Gyrd- Hansen: A conserved ubiquitin-binding domain links Inhibitor of Apoptosis Proteins to NF-kB signalling and cell survival
Martin Leverkus: The Inhibitor-of-apoptosis (IAP) protein family member XIAP is an important downstream regulator of death receptor-mediated apoptosis
Lorna Flanagan: Quantitative live cell imaging suggests a role for XIAP in regulating mitochondrial outer membrane permeabilisation (MOMP) during TRAIL-induced apoptosis
10:15 – 11:00 coffee break
11:00 – 12:30 Bcl-2 family members in apoptosis (Seamus Martin / Peter Daniel)
Grant Dewson: To trigger apoptosis Bak exposes its BH3 domain and homo-dimerizes via BH3: groove interactions
Peter T. Daniel: Role of p21, Bax and Bak in TRAIL–induced apoptosis in human carcinoma
Markus Rehm: Predictive live cell imaging elucidates the real-time kinetics of pore formation in the outer mitochondrial membrane and detects spatial waves of cytochrome-c release during apoptosis
Seamus J. Martin: Bax or Bak-induced Mitochondrial Fission can be uncoupled from Cytochrome c release and apoptosis
Marco Colombini: Mitochondria-ediated apoptosis: the role of ceramide channels
Philipp J. Jost: The role of endogenous pro-survival Bcl-2 family members in the development and sustained growth of tumours
12:30 – 14:00 lunch
14:00 – 15:30 Bcl-2 family members in apoptosis (continued)
Verena Labi: Loss of the BH3-only protein PUMA rescues mice from γ-irradiation-induced lymphomagenesis
Dana Westphal: The orf virus protein 125 is a Bcl-2–like inhibitor of apoptosis that binds BH3–only proteins but not Bax and Bak
Cristina Quintavalle: Akt modulates the half life and cellular localization of Bcl–w
Chiel Maas: Unusual cleavage of Bid is instrumental in DNA damage–induced apoptosis
Felix M. Wensveen: Deficiency of the BH3-only protein NOXA extends survival of activated lymphocytes
Franziska B. Mullauer: Betulinic Acid induces cell death in cancer cells via multiple pathways
15:30 – 16:15 coffee break
16:15 – 17:00 Sensitising Cancer Stem Cells (Jan Paul Medema / Huseyin Mehmet)
Maria Giovanna Francipane: SOCS family molecules sensitise anaplastic thyroid cancer cells to chemotherapy
Ylenia Lombardo: Bone morphogenetic protein 4 induces differentiation of colon CSCs
Louis Vermeulen: Chemoresistance in Colon Cancer Stem Cells
17:00 – 20:00 Poster Session I (presenting authors: A-L)
20:00 – 22:00 Dinner