BCL2 family and mitochondria

Chairs: Andreas Villunger & Thomas Kaufmann

9:00                      Welcome

9:05    Andreas Villunger: Introduction

9:15    Andreas Villunger: BH3-only proteins Bim and Bmf limit B cell survival in the absence of BAFF

9:30    Gabriel Ichim: Failure to execute apoptosis results in mitochondrial dependent DNA damage

9:45    Raquel Salvador Gallego: Microscopy approaches to investigate Bax dynamics and structure in living cells.

10:00  Luca L. Fava: Investigating the molecular mechanism of cell death upon mitotic arrest

10:15  Maja Sochalska: Investigating the role of Bcl2a1/A1/Bfl-1 in tumorigenesis

10:30                      Coffee break

11:00  Thomas Kaufmann: Investigating Molecular Functions of BOK and its Role in Cancer

11:15  Ameeta Kelekar: Noxa regulates glutamine metabolism through a mechanism independent of its BH3 domain

11:30  Dimitra Masouras: The role of IkB kinase (IKK) in the regulation of BH3-only proteins, downstream of cytokine signalling

11:45  Stephanie Bleicken: Structure of active Bax at the membrane

12:00  Matthias Kollek: Transient apoptosis inhibition in donor stem cells during hematopoietic stem cell transplantations

12:15  Nathiya Muthalagu: Bim is required and p19ARF is dispensable for Myc induced apoptosis in multiple solid tissues

13:00                      Lunch

Caspases, FLIP, the ripoptosome 

Chairs: Marion MacFarlane & Annika Meinander

15:05  Marion MacFarlane: Introduction

15:15 Michelle A. Hughes: The ‘FLIP’ side of the DISC – New Insights into c-FLIP Regulation of Caspase-8 Function

15:30 Jeanne A. Hardy: Allosteric Regulation of Apoptotic Caspases

15:45  Maximilian Wuerstle: Integrated data analysis demonstrates that Procaspase-9 is activated as a monomer on the apoptosome backbone

16:00  Sebastian Horn: The initiator caspase-10 protects from death receptor-induced cell death

16:15  Christian Widmann: Caspase-3 generates a NFkB repressor in response to stress

16:30                      Coffee break

17:00  Raffaella Iurlaro: Caspase-8 activation in response to glucose deprivation

17:15  Christian T. Hellwig: Employing a novel activation platform for the initiator caspase-8 to induce apoptosis in chemo-resistant cancer cells

17:30  Mason Sanders: Single cell analysis of inflammatory caspase activation

17:45  Dominique Kranz: Synthetic lethal RNAi screen identifies the atypical cadherin FAT1 as an antagonist of caspase-8

18:00  Annika Meinander: Negative regulation of DIAP2 activity and innate immunity by drICE

18:15  Gianmaria Liccardi: The ripoptosome: a double edged sword of the mitotic checkpoint

19:00                      Dinner

20:30  Poster session 1 – even-numbered posters