Breakfast
9:00 – 9:15 Introduction/welcome
09:15 Session 1 – Tumorigenesis
Chairs: Mads Daugaard; Peter Kreuzaler
Kai Cao, University of Glasgow
Apoptosis as an oncogenic driver – mechanism and impact on cancer
Thomas Kaufmann, University of Bern
Role of BOK in Cancer
Yuchen Guo, University of Montpellier
The role of cyclin A2 in colon homeostasis and colorectal cancer (CRC)
Michael Hahne, University of Montpellier
Primary cilia modulate susceptibility to colon carcinogenesis
Ulrike Hoeckendorf, Technical University of Münich
Evasion of LT–driven inflammatory cell death promotes myeloid leukemogenesis
10:30 Coffee break
11:00 Session 2 – Cancer invasion
Chairs: Mahvash Tavassoli; Brent Derry
Antonella De Cola, D’Annunzio University
MiR-205-5p promotes invasion and metastasis in breast cancer stem cells
Lazaros, Vasilikos, University of Zurich
Loss of cIAP1 in the tumor microenvironment disfavors cancer metastasis
Simone Di Franco, University of Palermo
Paracrine action of visceral adipose-derived mesenchymal stem cells promote the switch from epithelial (CMS2) to mesenchymal (CMS4) phenotype in colorectal cancer stem cells.
Peter Kreuzaler, Francis Crick Institute
Obligatory Tumour Heterogeneity driven by Myc Overexpression: Mechanistic Insights and Therapeutic Strategies
Seamus Martin, Trinity College
Stress-induced inflammatory functions of ‘death receptors’
12:30 Lunch
15:00 Session 3 – Autophagy, ferroptosis
Chairs: Markus Conrad; Anne Hamacher-Brady
Ian Gentle, Universitätsklinikum Freiburg
Inhibitor of Apoptosis Proteins Regulate Autophagosome-Lysosome fusion
Kayleigh Frame, MRC Toxicology Unit
Dissecting the Link between Bioenergetic Status and Autophagy as a Mechanism of Tumour Cell Resistance to BH3 Mimetics
Samya Van Coillie, VIB Center for Inflammation Research
Novel third-generation ferrostatins protect against acute iron poisoning-induced organ injury
Lukas Peintner, University of Freiburg
The influence of apoptosis on the development of polycystic kidney disease (ADPKD)
Alessandro Terrinoni, University of Rome
The role of TGase3 in ultraviolet photodamage
16.30 Coffee break
17.00 Session 4 – Gamechanging Science I
Chairs: Uris Ros; Beat Bornhauser
Joyce Buikhuisen, Center for Experimental Molecular Medicine
CRISPR-based kinome knock-out screen identifies PAK2 as an essential kinase in poor prognosis mesenchymal colorectal cancer.
Janneke Linnekamp, Center for Experimental Molecular Medicine
Consensus Molecular Subtypes of colorectal cancer are recapitulated in in vitro and in vivo models.
Prashanthi Ramesh, LEXOR
A drug screen to identify optimal combination strategies to overcome BCL-xL specific stem cell resistance in colorectal cancer
Ulrich Maurer, University of Freiburg
CDK9-mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery
Laura Mainz, University of Würzburg
Arginine depletion induced senescence-like growth arrest facilitates senolytic therapy in pancreatic cancer cells
19.30 Dinner
21:00 Poster session 1 – No 1-49