7.30 – 9.00: Breakfast
9.00 – 11.00: Caspases and their Substrates (Vincenzo De Laurenzi and Andreas Villunger)
Seamus Martin: Understanding the demolition phase of apoptosis.
Antoine Tinel: Identification of a caspase-2 activating complex.
Thomas Hofmann: FLASH links CD95 (Fas/APO-1) signaling to a novel PML-nuclear body-associated apoptosis pathway.
Maya Saleh: Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.
Petra Ovaere: Caspase-14 expression, regulation and processing during epidermal differentiation.
Jiang-yan Yang: Partial cleavage of RasGAP by caspases is required for survival in mild stress conditions.
Xavier Saelens: Translational control in apoptosis versus necrosis.
11.00 – 11.30: Coffee break
11.30 – 13.15: Inhibitor of Apoptosis Proteins (Seamus Martin and Cristina Munoz-Pinedo)
Marion MacFarlane: Caspase activation impedes proteasome function during apoptosis: siRNA targeting of XIAP.
Pascal Meier: Ubiquitin-mediated regulation of cell death.
Tencho Tenev: Drosophila DIAP1 interacts with caspases through an evolutionarily conserved mechanism that is distinct from XIAP.
John Silke: Homeostatic regulation of IAP protein levels.
Luis Miguel Martins: Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.
José Rodriguez: A novel role for Survivin-DEx3: regulation of Aurora B sub-cellular distribution during interphase.
13.15 – 15.00: Lunch
15.00 – 16.15: Death Receptors I (Katharina Simon and Henning Walczak)
Martin Leverkus: cFLIPL inhibits TRAIL-mediated NF-kB activation and apoptosis induction in human keratinocytes.
Gustavo Ortiz-Ferron: Activation of the mitogen-activated protein kinase (MAPK) pathway attenuates TRAIL-induced apoptosis by preventing tBid-mediated release of cytochrome c from mitochondria in breast tumor cells.
Martin Sprick: Distinct but overlapping substrate specificities of caspase-10 and caspase-8.
Ann Zeuner: Ineffective death receptor signaling in polycythemia vera erythroid progenitor cells.
16.15 – 16.45: Coffee break
16.45 – 18.00: Death Receptors II (Doug Green and Martin Leverkus)
Annika Meinander: Heat stress down-regulates c-FLIP and sensitises cells to Fas receptor-mediated apoptosis.
Inna Lavrik: CD95 signaling by the combination of bioinformatical and experimental approaches.
Ueli Nachbur: The role of lipid rafts in the regulation of Fas ligand activity.
Stefanie Fas: HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP).
19.00: Drinks Reception and Gala Dinner