8:00 – 9:00 Breakfast

9:30 – 11:15   Expression and processing of TNF family members (Michel Hahne, Giorgio Stassi)

Kerstin Herzer: MECHANISM OF TGF-ß INDUCED APOPTOSIS IN HEPATOMA CELLS

Anne Grosse-Wilde: BIOCHEMICAL ANALYSIS OF MURINE TRAIL RECEPTORS

Raymond Daniels: TRAIL and TRAIL receptor expression in normal and malignant tissues.

Carmen Ruiz de Almodóvar: UP-REGULATION OF TRAIL RECEPTORS IN BREAST TUMOR CELLS UPON GENOTOXIC TREATMENT

Marta López Fraga: INTRACELLULAR PROCESSING OF APRIL, A TNF LIGAND FAMILY MEMBER

Marcello Pinti: GENETIC POLYMORPHISMS OF FAS (CD95) AND FASL  (CD178) IN HUMAN LONGEVITY: STUDIES ON CENTENARIANS

 

11:15 – 11:45 Coffee break

11:45 – 13:00 TNF like ligands: Biology and novel signalling (Giorgio Stassi, Michel Hahne)

Desiree Bonci: APRIL IS AN AUTOCRINE GROWTH FACTOR FOR MEGAKARYOCYTES

Alena Vaculová: Tumour necrosis factor-alpha-induced cell death in colon cancer cells

Wiebke Baum: IDENTIFICATION OF PROTEINS INTERACTING WITH THE INTRACELLULAR DOMAIN OF CD95LIGAND

Christoph Wasem: REVERSE SIGNALLING VIA DEATH LIGANDS OF THE TUMOR NECROSIS FACTOR SUPERFAMILY

 

13:00 – 15:00 Lunch

15:00 – 16:45 Assembly and inhibition of signalling complexes (Henning Walczak, Ruggero De Maria)

Martin Sprick: Caspase-10 is recruited to and activated at death-inducing signalling complexes in a FADD-dependent manner

Tom Ganten: Enhanced Caspase-8 Recruitment to the DISC is Critical for Sensitisation of Human Hepatoma cells to TRAIL-induced Apoptosis BY CHeMOTHERAPEUTIC DRUGS

Fabio Martinon: THE INFLAMMOSOME – A NOVEL SIGNALLING COMPLEX INVOLVED IN INFLAMMATORY CASPASE ACTIVATION

Adriana Eramo: CD95 SIGNALLING IS INITIATED IN LIPID RAFTS

Francesco Lozupone: CD95/EZRIN INTERACTION IN THE CD95 APOPTOTIC PATHWAY

Andreas Krueger: c-FLIP splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex (DISC)

 

16:45 – 17:15 Coffee break

17:15 – 18:30 Regulation of cell death 1: at receptor level (Ruggero De Maria, Henning Walczak)

Kristina Archer: MECHANISM OF DECOY RECEPTOR REGULATION OF TRAIL CYTOTOXICITY IN LYMPHOCYTES

Astrid Ruefli: Mechanisms of P-glycoprotein-mediated inhibition of Fas-induced cell death

Cristina Muñoz-Pinedo: Inhibition of glucose metabolism sensitizes tumor cells to apoptosis induced by TRAIL, cd95 antibodies and tnf

Olivier Disson: REGULATION OF HEPATOCYTE APOPTOSIS IN A TRANSGENIC MODEL OF HCV INFECTION

 

20:00 Dinner