Cancer
Chairs: Vincenzo diLaurenzi & Jan-Paul Medema
9:00 Michael Hahne: The tubulin glycylase TTLL3 links primary cilia to colon cancer development
9:15 Paul A Townsend: Effect of histone deacetylase inhibitors on Notch signalling in the epidermis
9:30 Erik Slinger: CLL development is accelerated in mice deficient for pro-apoptotic regulator Noxa
9:45 Monika Mortensen: Targeting the autolysosomal compartment to improve acute leukemia treatment
10:00 Alessandro Annibaldi : The Role of the UBA domain of cIAP1 in Normal Cell Physiology and Tumorigenesis
10:15 Najoua Lalaoui: New therapeutic strategy to sensitize primary cancer cells to SMAC mimetics: use of p38 inhibitors
10:30 Coffee break
11:00 Mads Daugaard: Utilizing Plasmodium falciparum placental tropism to target a common oncofetal glycosaminoglycan signature on tumor cells
11:15 John Babcook: A Novel Antibody-Drug Conjugate Platform Demonstrating Potent Anti-Tumour Activity
11:30 Anette Brockmann: Thiazolides, GSTP1 and Colon Cancer Cell Apoptosis
11:45 Selcuk Colak: ER-stress induced UPR sensitizes chemotherapeutic resistant colon Cancer Stem Cells
12:00 Rosa Martín-Pérez: Cross-talk between Her2/ERBB2 signaling and the unfolded protein response in the regulation of apoptosis
13:00 Lunch
and more Cancer
Chairs: Mads Daugaard & Huseyin Mehmet
15:00 Antonella De Cola: miRNA mediated down-regulation of ErbB/HER receptors in Breast Cancer Stem cells results in targeted therapy resistance
15:15 Lisette Potze: New mechanistic insights in Betulinic acid-induced cell death
15:30 Cristina Muñoz-Pinedo: 2-deoxyglucose and glucose deprivation induce different forms of cell death
15:45 Gareth Miles: The Anti-Glycolytic Agent 2-deoxyglucose (2DG) Rapidly Activates the AMPK Pathway and Enhances TRAIL and ABT-737 -Induced Tumour Cell Death in Leukaemic Cells
16:00 Vincenzo Graziano: A DAXX/PML pathway for regulation of Estrogen Receptor expression and cell fate in Breast Cancer Stem Cells
16:15 Coffee break
Traditional EWCD football tournament
19:00 Dinner and party