9:15-10:45 -Session 10- CELL DEATH IN NON MALIGNANT DISEASE
Chairs: Katja Simon/ Marion McFarlane
– Desangher Solange -Characterization of a novel pathway regulating α-synuclein expression and neuronal death in Parkinson’s disease
– Granzotto Alberto -Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of alzheimer’s disease without reducing amyloid and tau pathology
– Delgado M.Eugenia -LRH-1-dependent regulation of TNF alpha-induced liver cell death
– Delvaeye Tinneke -Connexins as a new therapeutic target in the treatment of sepsis
– Townsend Paul Urocortin is chondroprotective through blockade of a non-selective cation channel: novel exploitable pathways for chondrocyte cytoprotection in osteoarthritis
– Xiao Mang MicroRNA (miR)-30 is responsible for radiation-induced apoptosis in mouse and human hematopoietic cells through targeting Mcl-1
10:45-11:15 Coffee Break
11:15-13:00 -Session 11- MOLECULAR MECHANISMS AND NEW METHODS
Chairs: Cristina Munoz Pinedo/Marja Jäättelä
– Melino Gerry-The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain
– Ruiz de Almodovar Carmen -Caspase-8 and FLIP as regulators of developmental angiogenesis
– Widmann Christian -Cellular homeostasis controlled by the caspase-3/RasGAP stress-sensing module
– Hughes Michelle The FLIP side of Death Receptor Signaling: New insights into c-FLIP regulation of Caspase-8
– Faletti Laura -Molecular mechanisms of TNFα sensitization to Fas/CD95-induced apoptosis
– McComb Scott -Multi-Colour LentiCRISPR Gene Disruption Demonstrates Caspase-3 and 7 Redundancy in Promoting Full Caspase-8 Activation and Apoptotic Cell Death
– Mørch Frøsig Merethe -Novel VitaBright™ probes can detect apoptosis based on thiol redox status
13:00-14:30 Lunch
14:30-16:15 -Session 12- ROLE OF MITOCHONDRIA AND AUTOPHAGY
Chairs: Chipuk, Jerry/Mehmet Hussein
– Chipuk Jerry Edward -BAX-dependent mitochondrial outer membrane permeabilization: exquisitely regulated to the point of death.
– Dewson Grant -VDAC2 is essential for Bax to efficiently mediate apoptosis
– Reljic Boris – A step closer to understanding Bax/Bak involvement in autophagy
– Riley Joel -An autophagy-independent pathway of mitochondrial clearance
– Jäättelä Marja – Sphingomyelin regulates ATG9A trafficking and autophagosome closure
– Simon Katharina -Autophagy determines the fate of hematopoietic cells
– Gentle Ian -Autophagy
17:00-19:00 Traditional football tournament
20:00 Dinner and party