9.00-10.45 Nuclear Aspects of “Death”

Vincenzo De Laurenzi: FLASH is an essential component of cajal bodies and is required for histone transciption and S-phase progression.

Brent Derry: Regulation of p53 by multiple SCF-based E3 ligases in C. elegans.

Catarina Grandela: Regulation of apoptosis of by p53 in human embryionic stem cells.

Paolo Salomoni: The role of Daxx in stress-induced cell death.

Paul Townsend: STAT-1: a modulator of apoptosis and cell cycle checkpoint responses.

Michael Ausserlechner: Regulation of Puma/bbc3 and Bcl-2 by p16INK4A sensitizes leukemia cells to Glucocorticoid- and Fas-induced apoptosis.

 

10.45-11.15 Lymphocyte-Associated Death (Nigel Watherhouse)

Ueli Nachbur: Post-transcriptional regulation of FasL killing activity by lipid rafts.

Ilia Voskoboinik: Unravelling the mechanism and function of perforin, a key effector molecule of the cytotoxic lymphocytes.

Nigel Waterhouse: Inhibition of caspases blocks granzyme B induced apoptosis in Bcl-2 over-expressing cells and promotes clonogenic survival

Michael Bots: The role of serine protease inhibitor SPI-6 in dendritic cells.

Carmen Ruiz-Ruiz: Regulation of primary T lymphocytes resistance to TRAIL-induced apoptosis

 

13.00-14.30 lunch

14.30-16.00 IAP family members

John Silke: Role of IAPs in TNF superfamily (TNFSF) signaling.

Martin Leverkus: Inhibition of IKK2 sensitizes human keratinocytes to (TNF)-induced apoptosis independent of cIAP2 upstream or at the level of caspase 8.

Markus Rehm: Effector caspase activation as an all-or-none response and its control by X-linked inhibitor of apoptosis protein (XIAP) – a quantitative systems biology analysis.

Paulo Ribiero: DIAP2, The drosophila orthologue of XIAP, controls the effector caspase DRICE through a novel mechanism.

Davina Twiddy: The ~700-kDa apoptosome complex directly processes caspase-7, which is then sequestered by XIAP into a stable ~200-kDa complex.

 

17.00-19.00 1st EWCD Football Cup (mixed)

20.00 BBQ and party