Breakfast
09:00 Session 11 – Necroptosis, death receptors and inflammation
Chairs: Mads Gyrd-Hansen; Anja Krippner-Heidenreich
Annette Jacobsen, Walter + Eliza Hall Institute of Medical Research
Compound X is a novel inhibitor of necroptosis in human cell lines.
Emma Petrie, Walter + Eliza Hall Institute of Medical Research
Formation of active human MLKL oligomers is tightly controlled by RIPK3.
Uris Ros, University of Tubingen
Structural insights into the auto-regulation of the necroptosis executor MLKL
Gabriela Brumatti, Walter + Eliza Hall Institute of Medical Research
RIPping leukaemias apart: Exploiting necroptosis to treat Acute Myeloid Leukaemia
Maximilien Bencze, UCL Great Ormond Street Institute of Child Health
Necroptosis participates in skeletal muscle degeneration in Duchenne Muscular Dystrophy
Graeme Sullivan, Trinity College
ER Stress-induced TRAIL receptor upregulation promotes inflammation
10:30 Coffee break
11:00 Session 12 – Gamechanging Science 2
Chairs: Gabriella Brumatti; Thomas Kaufmann
Mary Speir, Harvard Medical School
Negative regulation of apoptotic and necroptotic cell death by SHP1
Lisa Schlicher, Ludwig Institute for Cancer Research
Small-molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signalling
Ben Croker, Harvard Medical School
PAD4 negatively regulates neutrophil necroptosis
Paula Kroon, The Netherlands Cancer Institute
Hype, hope, or something in between? Achieving abscopal effects by radio-immunotherapy approaches
Nicole Rufo KU Leuven
Systems Biology of Immunogenic Cell Death (ICD) in Melanoma
Irmina Garcia-Carpio, Medical University of Innsbruck
Dissecting the molecular basis of sterile inflammation upon centrosome aberrations
12:30 Lunch
14:30 Session 13 – Gut
Chairs: Geert van Loo; Monica Yabal
Adam Wahida, Technical University of Munich
Molecular Characterization of the TNF-RIPK3-axis in Paneth cell Dysfunction and Dysbiosis as drivers of Inflammatory Bowel Disease in XIAP-Deficiency
Marc Healy, University Hospital Zurich
MCL-1 suppresses intestinal carcinogenesis by ensuring mucosal and stem cell homeostasis independent of microbiota-driven inflammation
Christa Kietz, Åbo Akademi University
drICE restrains DIAP2-mediated inflammatory signalling and intestinal inflammation
Eugenia Delgado, Ecole Polytechnique Federale de Lausanne
LRH-1-dependent regulation of intestinal epithelial cell death
Eric Chapman, University of Toronto
A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis in C. elegans
16:00 Football tournament
20.30 Gala Dinner