9:30-10:45 -Session 5- Cancer therapy
Chairs: Gerry Melino/Anastasis Stephanou
– Ellegaard Anne Marie-Repurposing cationic amphiphilic antihistamines for cancer treatment
– Jaime Paula -Immunogenicity of cytotoxic T cell-mediated cell death during cancer immunotherapy and its regulation by mutations associated with apoptosis resistance.
– Zimberlin Cheryl– Histone deacetylase (HDAC) inhibitors activate FOXOs in order to differentiate and sensitize colon cancer stem cells to chemotherapeutics
– Stephanou Anastasis-Tripterygium wilfordii, Amydalin and Graviola Induce cell death in Cancer Cells but not Normal Cells
– Bornhauser Beat -Concurrent apoptosis and necroptosis by SMAC mimetics eradicates drug resistant leukemia
10:45- 11:15 Coffee Break
11:15-12:45 -Session 6- RIP AND CANCER
Chairs: Peter Vandenabeele / Paul Townsend
– Aguadé-Gorgorió Júlia -A novel role for TNF receptor II in RIP1-dependent SMAC mimetic-induced cell death in leukemia
– Silke John -The caspase-8 inhibitor emricasan combines with the Smac-mimetic birinapant to induce necroptosis and treat Acute Myeloid Leukemia
– Philipp Jost -Evasion of necroptosis and inflammasome activation promotes myeloid leukemogenesis
– Aaes, Tania Løve – RIPK3-dependent necroptosis induces efficient anti-tumor immunity
– Wong Lynn – RIPK3 promotes vascular permeability and angiogenesis independent of the kinase activity
– Eun-Woo Lee Crosstalk between necroptosis signalling and oncogenic signalling
13:15-15:00 Lunch
15:00-16:30 -Session 7- RIP AND INFLAMMATION
Chairs: Mads Gyrd-Hansen/Seamus Martin
– Feltham Rebecca -Mind bomb concomitantly regulates RIPK1 and its opposing deubiquitylase CYLD to prevent cell death during TNF signalling
– Liccardi Gianmaria – The Mitotic Ripoptosome: Guardian of genomic integrity and tissue homeostasis
– Schuler Fabian -Understanding the molecular basis of cell death triggered by inhibition of Check-point kinase 1
– Sladky Valentina -Dissecting the role of caspase-2 in “mitotic catastrophe”
– Annibaldi Alessandro -The E3 Ubiquitin ligases cIAP1 and cIAP2 differentially target RIPK1 to prevent cytokine-mediated apoptosis and necroptosis
– Bouchier-Hayes Lisa -DNA damage induces PIDD-dependent activation of caspase-2 in the nucleolus.
16:30-17:00 Coffee Break
17:00-19:00 POSTER VIEWING WITH APERITIF
19:00 dinner