7:00 – 9:00 Breakfast

9:00 – 10:30 Sensitising Cancer to apoptosis (Paul Ekert / Vincenzo De Laurenzi)

Michael Bots: Apaf-1 and caspase-9 are dispensable for HDACi– induced cell death of B cell lymphoma

Annelieke Jaspers: c-Abl Kinase inhibitors overcome CD40- mediated drug resistance in CLL; implications for therapeutic

targeting of chemoresistant niches

Michela Muscolini: Trichostatin A up-regulates p73 and induces Bax-dependent apoptosis in ovarian cancer cells

Simon Cook: Colorectal Cancer Cells are Addicted to Oncogene– Regulated Signalling Pathways for Repression of BIM and Growth Factor –Independent Survival

Ralph K. Lindemann: In vivo candidates screen identifies apoptotic pathways underlying HDAC inhibitor–mediated tumor therapy

Paul G. Ekert: Life and death of myeloid cells: Testing the requirements for cell death genes and transcription factors

 

10:30 – 11:00 coffee break

11:00 – 12:30 Sensitising Cancer to apoptosis (continued) (Ricky W. Johnstone / John Silke)

John Silke: Mechanism of apoptosis induction by IAP Antagonists

Ricky W. Johnstone: Synergistic tumor cell apoptosis mediated by vorinostat and ABT -737

Discussion I: Apoptosis therapeutics in the clinic: new impulses for basic cancer research or “much ado about nothing”? (Discussion leaders: Ricky W. Johnstone & John Silke)

 

12:30 – 13:45 lunch

13:45 – 15:30 Bus trip to Heidelberg

16:00 – 18:00 Visit to Heidelberg Castle

19:00 – 22:30 Dinner at Vetter`s Brewery in the Old Town of Heidelberg

22:30 – 00:30 Return by bus to Hauenstein