9.00-11.00 Caspase Regulation and Targets

Ina Lavrik: The role of two new c-FLIP proteins in life and death of cells.

Aura Kaunisto: Specific phosphorylation regulates the ubiquitylation and turnover of c-FLIP(S)

Christina Falschlehner: Caspase-3 and BID are differentially processed by Caspase-8 and Caspase-10.

Rüdiger Arnold: The caspase-3 target HPK1: A Molecular Switch between Life and Death in Hematopoietic Cells.

Magnus Olsson: A functional connection between p53 and Caspase-2 is essential for apoptosis induced by DNA damage.

Gavin McStay: In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.

Enrique Pérez-Payá: Small molecule inhibitors of apaf-1-related caspase-3/-9 activation that control mitochondrial-dependent apoptosis.

 

11.00-11.30 coffee break

11.30-13.15 Death Receptors

Thomas Kaufmann: Pro-Apoptotic BH3-only Bcl-2 Family Member Bid Is Required for FasL- but not for TNF-Mediated Fatal Hepatocyte Death and Dispensable for DNA Damage-Induced Apoptosis and Cell Cycle Arrest.

Brian Ferguson: Structural and biochemical analysis of the death domain complex formed at the Fas receptor.

Fiona Kimberley: Abnormal disulphide linked oligomers, global misfolding and intracellular retention of receptors underlies pathology in Tumour Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS).

Thomas Brunner: Loss of TRAIL protects from Fas (CD95)-induced hepatoxicity and lethality.

Anne Grosse-Wilde: The apoptosis-inducing TRAIL-receptor is a metastasis suppressor in a multi stage skin tumor mouse model.

Marion Macfarlane: Receptor-selective trail mutants reveal that primary lymphoid tumor cells signal to apoptosis via TRAIL-R1: implications for therapy.

 

13.30-14.30 lunch

14.30-21.30 Trip to castle + dinner