Breakfast
09:00 Session 5 – TNF signaling and inflammation
Chairs: Markus Rehm Morrison; Diana Panayotova-Dimitrova
Yves Dondelinger, VIB Center for Inflammation Research
Phosphorylation of RIPK1 Ser25 controls TNF-induced cell death and inflammation
Gianmaria Liccardi, Institute of Cancer Research
RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development
Joanna Fox, MRC Toxicology Unit
Molecular Architecture and Mechanism of Death-Inducing Signalling Complex (DISC) Assembly
Rune Busk Damgaard, University of Cambridge
Interplay between TNF-secreting hyper-inflammatory cells and TNF-hypo-responsive cells prone to cell death in OTULIN-Related Autoinflammatory Syndrome (ORAS)
Carmen Palacios, Andalusian Center for Molecular Biology and Regenerative Medicine
Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis
10:15 Coffee break
10:45 Session 6 – Ubiquitin in cellular function
Chairs: Annika Meinander; Sheila Bohler
Anne Hamacher-Brady, Johns Hopkins University Bloomberg School of Public Health
Ubiquitin-Controlled Endolysosomal Interactions with Mitochondria Regulate Bax-Mediated Mitochondrial Permeabilization
Geert van Loo, VIB Center for Inflammation Research
The ubiquitin binding function of A20 critically controls its anti-inflammatory and protective activities
Anna Aalto, Åbo Akademi University
Lubel-mediated M1-linked ubiquitination as a regulator of hypoxia responses
Monica Yabal, Technical University of Munich
XIAP and inflammatory cell death in innate immunity.
Theresa Louise Boye, Danish Cancer Society Research Center
Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair
12:30 Lunch
15:00 Session 7 – Cell death proteins in hematopoietic function
Chairs: Andreas Villunger; Gianmaria Liccardi
Mattia Zucca, Ludwig Institute for Cancer Research
CYLD regulates the function of human macrophages
Lisanne Spilgies, University of Zurich
Inhibitors of Apoptosis Proteins (IAPs) regulate immune response to Influenza A infection
Ruoshi Peng, Ludwig Institute for Cancer Research
RIPK3-mediated inflammatory signalling in innate immune defence
Sheila Bohler, University of Freiburg
Deciphering the role of MCL-1 for maintenance of the human hematopoietic system
Christian Molnár, University of Freiburg
PUMA-mediated apoptosis of hematopoietic stem cells is a major driver of bone marrow failure in dyskeratosis congenita
16.30 Coffee break
17.00 Session 8 – Cell death and inflammation
Chairs: Marion MacFarlane; Rune Busk Damgaard
Diana Panayotova-Dimitrova, University Hospital RWTH Aachen
cFLIP isoforms regulate apoptosis/necroptosis decision in keratinocytes in vivo
Holly Anderton, Walter + Eliza Hall Institute of Medical Research
INHIBITOR OF APOPTOSIS PROTEINS (IAPS) LIMIT COMMENSAL DRIVEN INFLAMATION IN THE SKIN
Chris Wang, University of British Columbia
Oncofetal chondroitin sulfate modifications in NF-kB pathway activation
Wei-Lynn Wong, University of Zurich
XIAP inhibits excessive TNFR2-induced inflammation through RIPK1/TAK1
Yaron Fuchs, Technion Israel Institute of Technology
Caspase-3 Regulates YAP-dependent Cell Proliferation and Organ Size
19.30 Dinner
21:00 Poster session 2 – NR 50-98