9:15-10:45 -Session 8- CELL DEATH AND INFLAMMATION

Chairs: Julian Pardo/John Silke

– Martin Seamus – IL-1 family cytokines as the canonical DAMPs and their interplay with neutrophil-derived proteases

– Clancy Danielle -Neutrophil-derived proteases act as amplifiers of inflammation through processing and activation of multiple IL-1 family cytokines.

– Conos Stephanie -Cell death is not essential for caspase-1 mediated Interleukin-1b activation and secretion.

– Hrdinka Matous -RIPK2 active conformation but not its kinase activity is essential for pro-inflammatory signalling

– Lamkanfi Mo – ASC specks are cytosolic platforms for caspase-8 activation and apoptosis that is suppressed by cFLIPL upregulation through the TLR4/TRIF signaling axis

– Terrinoni Alessandro -Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis and inflammation in keratinocytes and in mouse psoriatic model

 

10:45-11:15    Coffee Break

11:15-13:00 -Session 9- ROLE OF UBIQUITIN IN CELL DEATH

Chairs: Pascal Maier/ Annika Meinander

– Gyrd-Hansen Mads -CYLD limits Lys63- and Met1-linked ubiquitin at receptor complexes to regulate innate immune signaling

– Damgaard Rune Busk -The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity

– Darding Maurice -Mechanistic insight into how LUBAC deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death

– Schlicher Lisa -SPATA2 a novel member of the TNFR complex I and interaction partner of CYLD

– Kumar Mohan Aravind -LUBE is a novel E3 ubiquitin ligase conjugating M1-linked chains in NF-kappaB signaling in Drosophila.

– Lionnard Loïc –Trim proteins regulate BFL-1 ubiquitination and degradation

– Zucca Mattia – Ubiquitin binding domains as a tool to investigate PRR signalling complexes

 

13:00-14:30 Lunch

Social afternoon- Visit to the old city of Anagni

19:00 dinner