8:00 – 9:00 Breakfast
9:30 – 11:15 Cell death in the nervous system (Huseyin Mehmet, Klaus Schulze-Osthoff)
Flavia Troglio: The neuronal specific adaptor protein Rai (ShcC) inhibits apoptosis triggered by limited neurotrophic support or environmental stress by activating PI3K/Akt
Adeline Lesay: BCL-2 PROTECTION FROM CYTOCHROME C-INDEPENDENT Apoptosis IN MAPLE SYRUP DISEASE
Jacqueline Beesley: MUTANT PROTEOLIPID PROTEIN TRIGGERS APOPTOSIS IN OLIGODENDROCYTES THROUGH AN ER STRESS PATHWAY INVOLVING CASAPSE-12 ACTIVATION
Huseyin Mehmet: Induction of Apoptosis or Necrosis in neuronal PC12 cells depending on the redox state of NITRIC OXIDE
Catherine Regnier: TRAF4 deficiency results in defective neurulation
Pier Giorgio Mastroberardino: TG2 ablation reduces neuronal death in a murine model of Huntington’s disease
11:15 – 11:45 Coffee break
11:45 – 13:00 Apoptotic signalling (Klaus Schulze-Osthoff, Huseyin Mehmet)
Jiang-yan Yang: The N-terminal caspase-generated RasGAP fragmant protects cells by activating the Ras-PI3K-Akt pathway
Daniela Barilá: REQUIREMENT OF ABL CASPASE CLEAVAGE IN APOPTOTIC SIGNALLING
Mohamed Lamkanfi: TRANSLATION INHIBITION IN APOPTOSIS: CASPASE-DEPENDENT PKR ACTIVATION AND eIF2-a PHOSPHORYLATION
Julieta del Prete: mRNA degradation: a general, early apoptotic event induced by a specific pathway distinct from that leading to DNA degradation
13:00 – 15:00 Lunch at conference site
15:00 – 17:00 Non-caspase proteases in cell death and survival (Katharina Simon, Marja Jäättelä)
Marja Jäättelä: HSP70 DEPLETION INDUCES CATHEPSIN-MEDIATED TUMOR CELL DEATH AND ERADICATES TUMOR XENOGRAFTS IN IMMUNODEFICIENT MICE
Maria Høyer-Hansen: INVOLVEMENT OF MITOCHONDRIA, ENDOPLASMATIC RETICULUM AND LYSOSOMES IN PROGRAMMED CELL DEATH OF MCF-7 BREAST CANCER CELLS
Nicole Fehrenbacher: TNF-INDUCED DEATH OF MURINE EMBRYONIC FIBROBLASTS BECOMES CATHEPSIN B-DEPENDENT UPON IMMORTALISATION
Michael Bots: THE SERINE PROTEASE INHIBITOR PI-9/SPI-6 BLOCKS THE PERFORIN/GRANZYME B PATHWAY, WHICH RESULTS IN ESCAPE FROM CTL-MEDIATED CYTOTOXICITY
Ingrid Kolfschoten: IDENTIFICATION AND EXPRESSION OF THE SERINE PROTEASE INHIBITOR SPICI
Lucy Peltenburg: c-Myc-mediated apoptosis in p53-negative human melanoma cells
Diane Bolton: DEATH OF CD4+ T CELL LINES CAUSED BY HUMAN IMMUNODEFICIENCY VIRUS-1 DOES NOT DEPEND ON CASPASES OR APOPTOSIS
17:00– 17:30 Coffee break
17:30 – 19:30 Tumor therapy and counterattack (Katharina Simon, Marja Jäättelä)
Mads Daugaard: Specific depletion of hsp70 mrna and protein by small interference rna
Jennifer Rohn: ACTIVATION AND TRAFFICKING OF THE TUMOR-SPECIFIC APOPTOSIS-INDUCING PROTEIN APOPTIN
Alexandra Pietersen: The tumor-specific apoptosis inducing protein Apoptin in a transgenic mouse model
Valentina Screpanti: mISSING- self Recognition bY Perforin-Deficient NK cells
Katharina Simon: Breaking tumour tolerance: Fas ligand induces an anti-tumour response to melanoma antigens
Frederik Igney: Tumor Counterattack: Level and Time-Point of CD95L Expression are not Critical Factors in Mice
Veronica Huber: SECRETION OF FASL-BEARING MICROVESICLES AS A NOVEL MECHANISM OF LYMPHOCYTE APOPTOSIS INDUCED BY TUMOR CELLS
20:00 Dinner and party