Breakfast

09:00 Session 9 – Mitochondria – from powerhouse to slaughterhouse
Chairs: Cristina Muñoz-Pinedo; Rachel Uren

Ana J. Garcia-Saez, University of Tübingen
Mechanistic differences in Bax and Bak oligomerization at the single molecule level

Jerry Edward Chipuk, Icahn School of Medicine at Mount Sinai
MDM2 integrates cellular respiration and apoptotic signaling through NDUFS1 and the mitochondrial network.

Inge Verbrugge, Netherlands Cancer Institute
p32: From regulator of mitochondrial respiration to regulator of cell death?

Katiuscia Bianchi, Barts Cancer Institute
The innate immune kinase IKKε couples inflammation to aerobic glycolysis and serine metabolism.

Alba Roca Portoles, University of Glasgow
Mitochondrial stress signals inflammatory effects

Laura Hulea, McGill University
EIF4F Links Translation to Energy Stress Response in Cancer

 

10:30 Coffee break

11:00 Session 10 – Targeting bcl-2/mitochondria and cancer
Chairs: Stephen Tait; Ana Garcia-Sáez

Fabio Brocco, University of Amsterdam
BH3 mimetics as profiling tools: dissecting the role of individual Bcl-2 members in Venetoclax-resistant Chronic lymphocytic leukemia

Joan Montero, Institute for Bioengineering of Catalonia
Deciphering rational combination of targeted agents and BH3 mimetics using dynamic BH3 profiling

Marco Haselager, University of Amsterdam
Cross-talk between cytokine and NF-ĸB signaling in the CLL microenvironment can affect sensitivity for Venetoclax

Anna Guinot, University Children’s Hospital Zürich
Non-apoptotic cell death to eradicate resistant leukaemia

Karbon Gerlinde, Medical University of Innsbruck
Understanding the role of the BCL-2 protein family in the maintenance of genomic stability.

 

12:30 Lunch

14:00 off – social event

20.30 Dinner including round table discussions