7:30-8:15 Breakfast
8:30-10:20 Session I: Caspases (S. Srinivasula/R. De Maria)
Eric Eldering: BCR induced apoptosis is initiated by a zVAD insensitive protease which is under direct control of CD40.
Srinivasa Srinivasula: A regulatory role for Apaf 1 in caspase 9 function.
Colin Adrain: DRADD is a nuclear-localized death domain adaptor protein that binds caspase-9 and promotes apoptosis.
Astrid Danen-van Oorschot: Apoptin induces apoptosis specifically in human tumor cells: studies on its mechanism.
Geert Van Loo: Two cell death pathways leading to necrosis and apoptosis: differential role of caspases and mitochondria.
Jean-François Eléouët: The viral nucleocapside protein of the transmissible gastroenteritis coronavirus, TGEV, is a target for caspase 6 and 7.
10:20-10:50 Coffee break
10:50-13:00 Session II: Mitochondria and cytotoxic drugs (R. Johnstone/V. Sutton)
Ricky Johnstone: Regulation of caspase-dependent but not caspase-independent cell death by the multidrug resistance protein, P-glycoprotein.
Paola Costantini: Oxidation of a critical Thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis.
Cristina Muñoz-Pinedo: Biochemical differences in apoptosis induced by CD95 ligation or thymidilate-syntase inhibition.
Vivien Sutton: Granzyme B induced apoptosis is regulated by pro- and anti- apoptotic members of the Bcl-2 family.
Maria Rita Rippo: GD3 Ganglioside induces apoptosis via direct mithocondrial damage in a Bcl-2 controlled fashion.
Luigi Ravagnan: Two distinct pathways leading to nuclear apoptosis.
Anna Stepczynska: Differential role of caspase 8 and Bid cleavage during CD95- and anticancer drug induced caspase activation.
13:00-14:30 Lunch at conference site
14:30-15:45 Session III: Signaling (J.P. Medema/J. Borst)
Marjatta Rytömaa: Activation of the caspase cascade and the effect of Ras in detachment induced apoptosis.
Bryan Ballif: Regulation of cell survival by the MAPK-activated kinase, RSK1 and the phosphoinositide-dependent kinase, PDK1.
Daniela Barilá: A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK.
Antonio J. Vila-Coro: Chemokine receptor homo- and heterodimerization as a cellular mechanism to increase sensitivity and dynamic range of chemotaxis.
15:45-16:15 Coffee break
16:15-18:20 Session IV: Neurology (H. Mehmet/M. Leist)
Huseyin Mehmet: Fas/CD95/APO-1 can function as a death receptor for neuronal cells in vitro and in vivo and is upregulated following cerebral hypoxic-ischemic injury to the developing rat brain.
Marcel Leist: Differential effects of Bcl-2, caspase inhibition and PARP deletion on survival of intracerebral neuronal transplants.
Deana Demjen: Apoptosis contributes to neuronal lost following spinal cord trauma.
Ana Martin-Villalba: Synergistic inhibition of CD95 ligand and TNF attenuates brain damage in stroke.
Christiane Volbracht: ATP-control of neuronal apoptosis triggered by microtubule breakdown.
Vincenzo De Laurenzi: Functional studies on p73.
Luciano D’Adamio: Cleavage of Alzheimer’s b-amyloid precursor protein by g-secretase liberates an intracellular peptide that promotes apoptosis.
