8.45 – 10.15 Bcl-2 family
Chairs: P. Ekert
08.45 – 09.00 Introduction by Paul Ekert
09.00 – 09.15 Paul Ekert: Novel Mechanisms Regulating Bcl-2 protein family expression
09.15 – 09.30 Thomas Kaufmann: Towards understanding the functions of the Bcl-2 family member Bok
09.30 – 09.45 Ana Garcia Saez: Differences in the mechanism of membrane permeabilization by Bax and Bcl-xL relate to their function in apoptosis
09.45 – 10.00 Frank Edlich: Pro-survival Bcl-2 proteins retrotranslocate mitochondrial Bax into the cytosol
10.00 – 10.15 Fabien Llambi Bcl-2 protein dynamics in the regulation of life and death
10.15 – 10.45 Coffee break
10.45 – 12.30 Death receptor signaling
Chairs: Marion MacFarlane, Martin Leverkus
10.45 – 11.00 Introduction by Marion MacFarlane
11.00 – 11.15 Marion MacFarlane: A new DISC Model reveals a crucial role for Caspase-8 chain assembly in mediating Apoptotic Cell Death
11.15 – 11.30 Michele Hughes: A reconstituted TRAIL DISC model reveals new insights into c-FLIP regulation of procaspase-8
11.30 – 12.15 Christophe Le Clorennec: The Role of the new c-FLIP binding proteins Ku70 and Rack1 in Death Receptor mediated apoptosis: Rack1 and the DUB Ku70 : Novels regulators of c-FLIP function
12.15 – 12.30 Selcen Öztürk: Regulation of NF-κB activation by c-FLIP proteins and c- FLIP novel binding partners
12.30 – 12.45 Diana Panayotova Dimitrova: Epidermal cFLIP is a critical regulator of skin homeostasis and protects embryonic development in mice
13.00 – 14.30 Lunch
15.00 – 16.30 Pattern-recognition receptors and IAPs
Chairs: Pascal Meier, John Silke
15.00 – 15.15 Introduction by John Silke
15.15 – 15.30 John Silke: IAPs, RIPK2 and regulation of NOD signalling
15.30 – 15.45 Joseph Evans: The RIPK1/TRAF2 interaction and its role in limiting induction of the non-canonical NF-kB pathway
15.45 – 16.00 Martin Leverkus: The Ripoptosome – a molecular complex differentially regulated by cFLIP isoforms: the importance of the intracellular balance of cIAPs and RIP1
16.00 – 16.15 Conor Kearney: Regulation of TNF-induced cytokine production by IAPs
16.15 – 16.30 Stephen Tait: Mitochondria are dispensable for RIP3K mediated necroptosis
16.30 – 16.45 Najoua Lalaoui : RIP1 Kinase Activity is required for Cancer Cell Death Induced by SMAC Mimetics
16.45 – 17.15 Coffee break
17.15 – 19.15 XIAP and some TNF signalling Chairs: Pascal Meier, Mads Gyrd-Hansen
17.15 – 17.30 Pascal Meier: Caspase -9, APAF and IAPs and innate immunity
17.30 – 17.45 Mads Gyrd-Hansen: XIAP ubiquitylates RIPK2 and recruits LUBAC to regulate innate immune signaling
17.45 – 18.00 Donia Moujalled: RIPK3 sensitizes cells to killing by TNF without recruitment to complex 1, in the absence of caspase 8 and RIPK1
18.00 – 18.15 Monica Yabal: Consequences for Innate Immune responses upon loss of XIAP
18.15 – 18.30 Philip J. Jost: Inhibition of IAP proteins blocks pattern-recognition receptor-mediated fatal hepatitis in mice
18.30 – 18.45 Rune B. Damgaard: Disease-associated mutations in XIAP cause defective innate immune signalling
19.15 – 20.30 Dinner
20.30 – 22.00 Poster session I
