The 9th European Workshop on Cell Death
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Death with Aphrodite
EWCD- meeting held in Cyprus at the aquamare hotel.
March 30 to Friday 4th April, 2014
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Autophagy and the lysosome
Chairs: Monika Mortensen & Cristina Munoz-Pinedo
9:00 Monika Mortensen: short introduction
9:10 Tom Riffelmacher: Autophagy controls terminal differentiation of neutrophils
9:25 Anne Louise Hansen: Autophagy controls inflammation in the aging organism
9:40 Ghadir Almuhaini: HPV E6 Modulation of Autophagy
9:55 Sonja Aits: Galectins-1 as a novel marker for lysosomal membrane permeabilization
10:10 Søren Høgh: Regulation of lysosomal cell death by lysosomal ions and the TRPML1 ion channel
10:25 Coffee break
Cell death in the immune system
Chairs: Gustavo P. Amarante-Mendes & Huseyin Mehmet
11:00 Julian Pardo : Fast and efficient in vivo elimination of chemoresistant leukemia cells overexpressing Bcl-XL by granzyme B of cytotoxic T cells
11:15 Maykel Arias: During a bacterial infection cytotoxic T cells employ the pro-apoptotic protease granzyme B to eradicate bacteria meanwhile inflammation induced by NK-derived granzyme A causes sepsis
11:30 Gustavo P. Amarante-Mendes: Novel role for galectin-1 in CTL killing
11:45 Anja Krippner-Heidenreich: Dendritic cell survival and maturation are differentially regulated by TNF receptors 1 and 2
12:00 Selma Tuzlak: Analysis of the role of anti-apoptotic A1/Bfl-1 in experimental autoimmune encephalomyelitis
13:00 Lunch
Necroptosis and inflammation
Chairs: Seamus J. Martin & John Silke
15:00 Seamus J. Martin: Crosstalk between Cell Death and Inflammatory Signaling: Challenging Preconceptions
15:15 Scott McComb: Type-I Interferon Signalling is Necessary for Inflammatory Necroptosis of Macrophages
15:30 Monica Yabal: XIAP restricts TNF-dependent necroptosis and excessive inflammasome activation
15:45 Svetlana Saveljeva: Mechanism of ER Stress-Induced Necroptosis
16:00 Tania Løve Aaes: Necroptosis, a novel approach for cancer therapy?
16:15 Fumiyo Ikeda: Sharpin prevents TNFR1-induced keratinocyte apoptosis and skin inflammation by linear ubiquitination of FADD
16:30 Coffee break
Inflammation and NF-kappaB
Chairs: Seamus J. Martin & John Silke
17:00 John Silke: At the crossroad of inflammation and cell death – is there a therapeutic angle?
17:15 Mar Orzaez: Identification of new inflammasome inhibitors targeting ASC-mediated caspase-1 activation
17:30 Karina Bortoluci: Role of lysosomal pathway induced by cytosolic flagellin in cell death and immunity
17:45 Dagmar Kulms: Identification of new IkBa complexes by an iterative experimental and mathematical modeling approach
18:00 Nima Etemadi: TRAF2 regulates canonical and non canonical NFkB signalling to inhibit cell death and inflammation in skin independently of Sphingosine Kinase 1
18:15 Tom Vanden Berghe: Simultaneous targeting of Interleukin-1 and -18 is required for protection against inflammatory and septic shock
19:00 Dinner
20:30 Poster session 2 – odd-numbered posters
Death receptor signaling and IAPs
Chairs: Martin Leverkus & Giorgio Stassi
9:00 Mathieu JM Bertrand: An NF-kB-independent role of IKKs in regulating RIPK1 killing potential
9:15 Rebecca Feltham: MIB and SOB1 are novel RIPK1 interacting molecules that regulate TNF signaling by controlling the balance between survival and death
9:30 Thomas Grabinger: Mechanisms of TNF induced cell death in intestinal epithelial cells
9:45 Martin Leverkus: cFLIP regulates skin homeostasis and protects from TNF-induced keratinocyte apoptosis
10:00 Joel S Riley: Identification of novel regulators of FLIP’s ubiquitination and degradation
10:15 Lynn Wong: IAPs and RIPKs modulate sensitivity to TNF induced apoptosis and cancer formation
10:30 Coffee break
Ubiquitin and IAPs
Chairs: Pascal Meier & Mads Gyrd-Hansen
11:00 Pascal Meier: Regulation of the ubiquitin E3 ligase cIAP1
11:15 Kate Lawlor: IAP proteins repress spontaneous inflammatory joint disease
11:30 Simone Wicki: Role of XIAP in murine neutrophils downstream of death receptors and in response to danger signals
11:45 Anna Aalto: Characterization of M1-linked linear ubiquitylation in NF-kappaB signaling in Drosophila
12:00: Solange Desagher: Reciprocal regulation of Trim17 and NFATc3: implication in neuronal apoptosis
12:15 Mads Gyrd-Hansen: The deubiquitinase OTULIN regulates LUBAC function and NF-kappaB activation through a direct interaction with HOIP
13:00 Lunch
social afternoon
Cancer
Chairs: Vincenzo diLaurenzi & Jan-Paul Medema
9:00 Michael Hahne: The tubulin glycylase TTLL3 links primary cilia to colon cancer development
9:15 Paul A Townsend: Effect of histone deacetylase inhibitors on Notch signalling in the epidermis
9:30 Erik Slinger: CLL development is accelerated in mice deficient for pro-apoptotic regulator Noxa
9:45 Monika Mortensen: Targeting the autolysosomal compartment to improve acute leukemia treatment
10:00 Alessandro Annibaldi : The Role of the UBA domain of cIAP1 in Normal Cell Physiology and Tumorigenesis
10:15 Najoua Lalaoui: New therapeutic strategy to sensitize primary cancer cells to SMAC mimetics: use of p38 inhibitors
10:30 Coffee break
11:00 Mads Daugaard: Utilizing Plasmodium falciparum placental tropism to target a common oncofetal glycosaminoglycan signature on tumor cells
11:15 John Babcook: A Novel Antibody-Drug Conjugate Platform Demonstrating Potent Anti-Tumour Activity
11:30 Anette Brockmann: Thiazolides, GSTP1 and Colon Cancer Cell Apoptosis
11:45 Selcuk Colak: ER-stress induced UPR sensitizes chemotherapeutic resistant colon Cancer Stem Cells
12:00 Rosa Martín-Pérez: Cross-talk between Her2/ERBB2 signaling and the unfolded protein response in the regulation of apoptosis
13:00 Lunch
and more Cancer
Chairs: Mads Daugaard & Huseyin Mehmet
15:00 Antonella De Cola: miRNA mediated down-regulation of ErbB/HER receptors in Breast Cancer Stem cells results in targeted therapy resistance
15:15 Lisette Potze: New mechanistic insights in Betulinic acid-induced cell death
15:30 Cristina Muñoz-Pinedo: 2-deoxyglucose and glucose deprivation induce different forms of cell death
15:45 Gareth Miles: The Anti-Glycolytic Agent 2-deoxyglucose (2DG) Rapidly Activates the AMPK Pathway and Enhances TRAIL and ABT-737 -Induced Tumour Cell Death in Leukaemic Cells
16:00 Vincenzo Graziano: A DAXX/PML pathway for regulation of Estrogen Receptor expression and cell fate in Breast Cancer Stem Cells
16:15 Coffee break
Traditional EWCD football tournament
19:00 Dinner and party
Breakfast and departure